iPTMnet Report for O75077 (ADAM23)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75077 / ADA23_HUMAN
Protein Name Disintegrin and metalloproteinase domain-containing protein 23 precursor
Gene Name Name: ADAM23
Synonyms:MDC3;
Organism Homo sapiens (Human)

PRO ID PR:O75077
DAG View
PRO Name disintegrin and metalloproteinase domain-containing protein 23 (human)
Definition A disintegrin and metalloproteinase domain-containing protein 23 that is encoded in the genome of human.
Short Label hADAM23
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75077 (ADAM23) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y119 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
T352 Phosphorylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
Y396 Phosphorylation PhosphoSitePlus
Y403 Phosphorylation PhosphoSitePlus
C408 Methylation IEDB 31844290
T453 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
Y707 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
Site PTM Type PTM Enzyme Score Source PMID
Y707 Phosphorylation HPRD 16094384


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T352 A352 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y396 C396 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y396 S396 Biomuta DOID:1324 / lung cancer [ cosmic ]
T453 K453 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S473 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S473 L473 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
Y707 H707 Biomuta DOID:2394 / ovarian cancer [ cosmic ]