iPTMnet Report for O75064 (DENND4B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75064 / DEN4B_HUMAN
Protein Name DENN domain-containing protein 4B
Gene Name Name: DENND4B
Synonyms:KIAA0476;
Organism Homo sapiens (Human)

PRO ID PR:O75064
DAG View
PRO Name DENN domain-containing protein 4B (human)
Definition A DENN domain-containing protein 4B that is encoded in the genome of human.
Short Label hDENND4B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75064 (DENND4B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y12 Phosphorylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
R303 Methylation PhosphoSitePlus
Y453 Phosphorylation IEDB 32387766
K506 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
S677 Phosphorylation PhosphoSitePlus
T680 Phosphorylation PhosphoSitePlus
T684 Phosphorylation PhosphoSitePlus
R731 Methylation PhosphoSitePlus
S732 Phosphorylation PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
K755 Ubiquitination PhosphoSitePlus
K862 Ubiquitination PhosphoSitePlus
T942 Phosphorylation PhosphoSitePlus
S947 Phosphorylation PhosphoSitePlus
S953 Phosphorylation PhosphoSitePlus   UniProt 23186163
K960 Ubiquitination PhosphoSitePlus
S963 Phosphorylation PhosphoSitePlus
R968 Methylation PhosphoSitePlus
T1052 Phosphorylation PhosphoSitePlus
T1066 Phosphorylation PhosphoSitePlus
S1068 Phosphorylation PhosphoSitePlus
S1071 Phosphorylation PhosphoSitePlus
S1074 Phosphorylation PhosphoSitePlus
S1092 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1134 Phosphorylation PhosphoSitePlus
K1221 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R303 Q303 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y453 N453 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S677 R677 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T942 A942 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R968 Q968 Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T1052 P1052 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1071 Y1071 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]