iPTMnet Report for O75061 (DNAJC6)
Protein Information
| UniProt AC / UniProt ID | O75061 / AUXI_HUMAN |
| Protein Name | Putative tyrosine-protein phosphatase auxilin |
| Gene Name | Name: DNAJC6 Synonyms:KIAA0473; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O75061 |
| PRO Name | putative tyrosine-protein phosphatase auxilin (human) |
| Definition | A putative tyrosine-protein phosphatase auxilin that is encoded in the genome of human. |
| Short Label | hDNAJC6 |
| Category | organism-gene |
DAG ViewO75061 (DNAJC6) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 22814378 | ||
| K38 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K42 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R95 | Methylation | score1 | PhosphoSitePlus | |||
| S112 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
| Y185 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y196 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S239 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T262 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S563 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
| T565 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
| S566 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| T567 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S570 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
| T572 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S654 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S658 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T696 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S709 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S714 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S745 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K850 | Methylation | score1 | PhosphoSitePlus | |||
| K852 | Methylation | score1 | PhosphoSitePlus | |||
| K867 | Acetylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S112 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| Y214 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S563 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T565 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S566 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T567 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S570 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T626 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T696 | Phosphorylation | score0 | HPRD | 19413330 | ||
| S709 | Phosphorylation | score0 | HPRD | 19413330 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K38 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K38 | N38 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] | |
| R95 | Q95 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| R95 | * | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
| S566 | P566 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| T567 | P567 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S709 | L709 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] |
