Protein Information

Cytoscape View


UniProt AC / UniProt ID O75038 / PLCH2_HUMAN
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
Gene Name Name: PLCH2
Synonyms:KIAA0450,PLCL4;
Organism Homo sapiens (Human)

PRO ID PR:O75038
DAG View
PRO Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (human)
Definition A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 that is encoded in the genome of human.
Short Label hPLCH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75038 (PLCH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y111 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
K617 Acetylation PhosphoSitePlus
K621 Acetylation PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus
T638 Phosphorylation PhosphoSitePlus
S931 Phosphorylation PhosphoSitePlus
T934 Phosphorylation PhosphoSitePlus
S1168 Phosphorylation PhosphoSitePlus
S1200 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
S1256 Phosphorylation PhosphoSitePlus
S1277 Phosphorylation PhosphoSitePlus
S1279 Phosphorylation PhosphoSitePlus
T1298 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1035 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S487 F487 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K617 Q617 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S635 F635 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T638 I638 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1168 N1168 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]