iPTMnet Report for O60942 (RNGTT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60942 / MCE1_HUMAN
Protein Name mRNA-capping enzyme
Gene Name Name: RNGTT
Synonyms:CAP1A;
Organism Homo sapiens (Human)

PRO ID PR:O60942
DAG View
PRO Name mRNA-capping enzyme (human)
Definition An mRNA-capping enzyme that is encoded in the genome of human.
Short Label hRNGTT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60942 (RNGTT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K28 Sumoylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
R34 Methylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K287 Sumoylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
Y300 Phosphorylation PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K423 Sumoylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K502 Acetylation PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
C565 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S210 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K290 N290 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S523 I523 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S523 R523 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]