iPTMnet Report for O60934 (NBN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60934 / NBN_HUMAN
Protein Name Nibrin
Gene Name Name: NBN
Synonyms:NBS,NBS1,P95;
Organism Homo sapiens (Human)

PRO ID PR:O60934
DAG View
PRO Name nibrin (human)
Definition A nibrin that is encoded in the genome of human.
Short Label hNBN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60934 (NBN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Acetylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
Y16 Phosphorylation PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
S58 Phosphorylation HPRD   PhosphoSitePlus 20068231
T60 Phosphorylation HPRD   PhosphoSitePlus 20068231
K73 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S104 Phosphorylation IEDB 35494241
K188 Ubiquitination PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
K208 Acetylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S213 O-Glycosylation GlyGen 23301498, 28411811, 34019948, ...35254053
K233 Acetylation PhosphoSitePlus
C269 Methylation IEDB 31844290
S278 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 15279770, 24614819, 14707289, ...25485873, 10839544, 12861053, 28369484
S278 Phosphorylation Q13315 (ATM) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 12861053, 15279770, 10839544
S292 Phosphorylation PhosphoSitePlus
K334 Acetylation PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
T336 Phosphorylation HPRD 20068231
T337 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163
S341 Phosphorylation HPRD   PhosphoSitePlus 19413330
S343 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 24614819, 15302935, 12447395, ...17525332, 23186163, 17957789, 11252893, 26869104, 10766245, 10839544, 10839545, 32479542, 23146902, 19413330, 18262646, 10608806, 18644472, 17526493, 12861053, 10802669, 19798429, 15279770, 17612497, 14707289, 32185127, 15314656, 18669648, 28369484, 14695167, 20068231
S343 Phosphorylation Q13315 (ATM) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 19413330, 15279770, 10608806, ...18644472, 11252893, 12447395, 18669648, 12861053, 10766245, 10839544, 10839545, 10802669, 14695167, 20068231
S343 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus   Signor 17526493, 18644472
S343 Phosphorylation Q99986 (VRK1) RLIMS-P+ 26869104
S347 Phosphorylation PhosphoSitePlus   UniProt 23186163
T367 Phosphorylation PhosphoSitePlus
K388 Methylation PhosphoSitePlus
S397 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17525332, 23186163, 11252893, ...18669648, 10839545, 20068231
S397 Phosphorylation Q13315 (ATM) HPRD   phospho.ELM   PhosphoSitePlus   Signor 18669648, 11252893, 20068231, ...10839545
T402 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S406 Phosphorylation HPRD 20068231
S418 Phosphorylation PhosphoSitePlus
T420 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
Y429 Phosphorylation HPRD   PhosphoSitePlus 17322306, 20068231
S432 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17322306, 23186163, 16964243, ...18767875, 18452278, 19651622, 18669648, 24275569, 22927831, 20068231
S432 Phosphorylation P24941 (CDK2) PhosphoSitePlus 22927831
T434 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S438 Phosphorylation HPRD   PhosphoSitePlus 20068231
K441 Acetylation PhosphoSitePlus
S442 Phosphorylation HPRD   PhosphoSitePlus 20068231
S447 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
C478 S-Nitrosylation dbSNO 26338901
T485 Phosphorylation HPRD 20068231
S488 Phosphorylation HPRD   PhosphoSitePlus 20068231
T493 Phosphorylation HPRD 20068231
T497 Phosphorylation HPRD   PhosphoSitePlus 20068231
S499 Phosphorylation HPRD 20068231
K504 Acetylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus   UniProt 23186163
T516 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus   UniProt 23186163
T524 Phosphorylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
K544 Acetylation PhosphoSitePlus
K550 Acetylation PhosphoSitePlus
K568 Acetylation PhosphoSitePlus
K582 Sumoylation PhosphoSitePlus
T602 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18452278
S604 Phosphorylation HPRD   PhosphoSitePlus 18452278
S611 Phosphorylation PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus
S615 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18077418, 18452278, 18669648, ...10839545, 20068231
S615 Phosphorylation Q13315 (ATM) PhosphoSitePlus   Signor 10839545
S615 Phosphorylation Q13535 (ATR) PhosphoSitePlus 18077418
K627 Ubiquitination PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
S661 Phosphorylation HPRD 20068231
K665 Acetylation PhosphoSitePlus
K665 Ubiquitination PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y679 Phosphorylation PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
K690 Acetylation PhosphoSitePlus
Y693 Phosphorylation PhosphoSitePlus
K698 Acetylation PhosphoSitePlus
S706 Phosphorylation PhosphoSitePlus
K715 Acetylation PhosphoSitePlus
K715 Methylation PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
K751 Methylation PhosphoSitePlus
K751 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O60934 (NBN) S432 Q15554 (TERF2) unknown eFIP 31825846


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y24 F24 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K82 E82 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S195 R195 Biomuta [ cosmic ]
Y197 C197 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S213 L213 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T337 N337 Biomuta DOID:11615 / penile cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
T337 I337 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S341 R341 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S418 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y429 H429 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S432 P432 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S447 Y447 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C478 W478 Biomuta DOID:1612 / breast cancer [ cosmic ]
T485 M485 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
T497 A497 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S499 L499 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K550 I550 Biomuta DOID:1324 / lung cancer [ cosmic ]
S615 F615 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K635 N635 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S661 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y679 H679 Biomuta DOID:263 / kidney cancer [ cosmic ]
K715 N715 Biomuta DOID:11615 / penile cancer [ cosmic ]