Protein Information

Cytoscape View


UniProt AC / UniProt ID O60880 / SH21A_HUMAN
Protein Name SH2 domain-containing protein 1A
Gene Name Name: SH2D1A
Synonyms:DSHP,SAP;
Organism Homo sapiens (Human)

PRO ID PR:O60880
DAG View
PRO Name SH2 domain-containing protein 1A (human)
Definition An SH2 domain-containing protein 1A that is encoded in the genome of human.
Short Label hSH2D1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60880 (SH2D1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y7 Phosphorylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
Y29 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K89 Acetylation PhosphoSitePlus   UniProt 19608861
K89 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
T115 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q99704 (DOK1) Y449 O60880 (SH2D1A) unknown eFIP 10852966


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K10 * Biomuta DOID:2531 / hematologic cancer [ tcga ]
S12 I12 Biomuta DOID:0070003 / blastoma [ cosmic ]
T114 S114 Biomuta DOID:1324 / lung cancer [ cosmic ]