Protein Information

Cytoscape View


UniProt AC / UniProt ID O60869 / EDF1_HUMAN
Protein Name Endothelial differentiation-related factor 1
Gene Name Name: EDF1
Organism Homo sapiens (Human)

PRO ID PR:O60869
DAG View
PRO Name endothelial differentiation-related factor 1 (human)
Definition An endothelial differentiation-related factor 1 that is encoded in the genome of human.
Short Label hEDF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60869 (EDF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895, 25944712
S4 Phosphorylation PhosphoSitePlus   UniProt 23186163
R13 Methylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K25 Methylation PhosphoSitePlus   UniProt 24129315
K25 Ubiquitination PhosphoSitePlus
K42 Acetylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K43 Acetylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
R72 Methylation PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
K79 Acetylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
T91 Phosphorylation P17252 (PRKCA) Signor 10816571
K93 Acetylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K102 Acetylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
K123 Acetylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
S4 Phosphorylation HPRD 19413330
S53 Phosphorylation HPRD 20068231
T74 Phosphorylation HPRD 20068231
T91 Phosphorylation P17252 (PRKCA) HPRD 10816571
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 19413330
S53 Phosphorylation HPRD 20068231
T74 Phosphorylation HPRD 20068231
T91 Phosphorylation P17252 (PRKCA) HPRD 10816571


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036239 (hEDF1/Ac:1) acM1 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S53 Y53 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R72 M72 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T91 M91 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]