Protein Information

Cytoscape View


UniProt AC / UniProt ID O60749 / SNX2_HUMAN
Protein Name Sorting nexin-2
Gene Name Name: SNX2
ORFNames:TRG9;
Organism Homo sapiens (Human)

PRO ID PR:O60749
DAG View
PRO Name sorting nexin-2 (human)
Definition A sorting nexin-2 that is encoded in the genome of human.
Short Label hSNX2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60749 (SNX2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S94 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus   UniProt 24275569
T104 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   UniProt 22028470, 24275569
T106 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
S117 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S119 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S127 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
S185 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
K197 Ubiquitination PhosphoSitePlus
Y203 Phosphorylation PhosphoSitePlus
K211 Acetylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
K218 Acetylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K223 Acetylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
R259 Methylation PhosphoSitePlus
S277 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...24275569, 20068231
R283 Methylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K335 Acetylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
K442 Methylation PhosphoSitePlus
K447 Acetylation PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K469 Acetylation PhosphoSitePlus   UniProt 19608861
K469 Ubiquitination PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T104 Phosphorylation HPRD 20068231, 18452278
S117 Phosphorylation HPRD 18669648
S119 Phosphorylation HPRD 18212344, 20230923, 19664994, ...20058876, 19651622, 18669648, 20166139
S185 Phosphorylation HPRD 18669648
S277 Phosphorylation HPRD 15302935, 19664994, 16964243, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S94 L94 Biomuta DOID:3963 / thyroid carcinoma [ icgc ] DOID:11934 / head and neck cancer [ tcga ]
K211 N211 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K223 N223 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T229 I229 Biomuta DOID:363 / uterine cancer [ tcga ]
T251 A251 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K516 T516 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]