Protein Information

Cytoscape View


UniProt AC / UniProt ID O60741 / HCN1_HUMAN
Protein Name Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Gene Name Name: HCN1
Synonyms:BCNG1;
Organism Homo sapiens (Human)

PRO ID PR:O60741
DAG View
PRO Name potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (human)
Definition A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of human.
Short Label hHCN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60741 (HCN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T41 Phosphorylation HPRD 20068231
S110 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
Y407 Phosphorylation PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
Y513 Phosphorylation PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S110 A110 Biomuta DOID:3571 / liver cancer [ tcga ]
S846 W846 Biomuta DOID:1324 / lung cancer [ tcga ]
S846 L846 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ icgc, tcga ]
S847 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
S847 P847 Biomuta DOID:363 / uterine cancer [ tcga ]