iPTMnet Report for O60741 (HCN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60741 / HCN1_HUMAN
Protein Name Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Gene Name Name: HCN1
Synonyms:BCNG1;
Organism Homo sapiens (Human)

PRO ID PR:O60741
DAG View
PRO Name potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (human)
Definition A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of human.
Short Label hHCN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60741 (HCN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T41 Phosphorylation HPRD   PhosphoSitePlus 20068231
S56 Phosphorylation PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
Y407 Phosphorylation PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
T472 Phosphorylation PhosphoSitePlus
Y513 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
T645 O-Glycosylation GlyGen 28657654, 29351928
T646 Phosphorylation PhosphoSitePlus
T700 O-Glycosylation GlyGen 28657654, 29351928
S770 Phosphorylation PhosphoSitePlus
T771 Phosphorylation PhosphoSitePlus
T807 O-Glycosylation GlyGen 28657654, 29351928
S846 Phosphorylation PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus
S872 Phosphorylation PhosphoSitePlus
S873 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S56 F56 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T99 I99 Biomuta DOID:3571 / liver cancer [ cosmic ]
S110 F110 Biomuta DOID:4159 / skin cancer [ cosmic ]
S110 A110 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S116 C116 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S599 L599 Biomuta DOID:4159 / skin cancer [ cosmic ]
S599 P599 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T646 N646 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T646 A646 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T700 N700 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S770 G770 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S770 N770 Biomuta DOID:4159 / skin cancer [ cosmic ]
T771 S771 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T771 K771 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T771 M771 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
T771 A771 Biomuta DOID:1324 / lung cancer [ cosmic ]
T807 S807 Biomuta DOID:1324 / lung cancer [ cosmic ]
S846 L846 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S846 W846 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S847 P847 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:8618 / oral cavity cancer [ cosmic ]
S847 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S871 F871 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S871 P871 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S872 F872 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S873 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]