iPTMnet Report for O60701 (UGDH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60701 / UGDH_HUMAN
Protein Name UDP-glucose 6-dehydrogenase
Gene Name Name: UGDH
Organism Homo sapiens (Human)

PRO ID PR:O60701
DAG View
PRO Name UDP-glucose 6-dehydrogenase (human)
Definition A UDP-glucose 6-dehydrogenase that is encoded in the genome of human.
Short Label hUGDH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60701 (UGDH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
S63 O-Glycosylation GlyGen 33214551, 30397120, 26853435, ...25367160, 34019948, 34229054
K67 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K107 Acetylation PhosphoSitePlus   UniProt 19608861
K107 Ubiquitination PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
K124 Acetylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K264 Acetylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
K329 Acetylation PhosphoSitePlus
K339 Acetylation PhosphoSitePlus
Y352 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
K355 Acetylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
C414 Methylation IEDB 31844290
K430 Ubiquitination PhosphoSitePlus
K434 Acetylation PhosphoSitePlus
T461 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
Y473 Phosphorylation PhosphoSitePlus   RLIMS-P 31243371
S476 Phosphorylation PhosphoSitePlus   UniProt 24275569
S483 Phosphorylation PhosphoSitePlus
K490 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T91 Phosphorylation HPRD 20068231
S476 Phosphorylation HPRD 19562805, 20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S47 Y47 Biomuta DOID:363 / uterine cancer [ icgc ]
S63 F63 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K67 E67 Biomuta DOID:2394 / ovarian cancer [ icgc ]
S88 Y88 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K170 N170 Biomuta DOID:1324 / lung cancer [ cosmic ]
S275 N275 Biomuta DOID:1319 / brain cancer [ icgc ]
T327 S327 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y352 S352 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K355 R355 Biomuta DOID:1324 / lung cancer [ cosmic ]
S386 * Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K490 R490 Biomuta DOID:1324 / lung cancer [ cosmic ]