iPTMnet Report for O60678 (PRMT3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60678 / ANM3_HUMAN
Protein Name Protein arginine N-methyltransferase 3
Gene Name Name: PRMT3
Synonyms:HRMT1L3;
Organism Homo sapiens (Human)

PRO ID PR:O60678
DAG View
PRO Name protein arginine N-methyltransferase 3 (human)
Definition A protein arginine N-methyltransferase 3 that is encoded in the genome of human.
Short Label hPRMT3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60678 (PRMT3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C2 Acetylation UniProt 19413330, 22814378, 22223895
S3 Phosphorylation PhosphoSitePlus
S25 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 18669648, ...21059412, 19690332, 20068231
S27 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 18669648, ...21059412, 20068231
K81 Methylation PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus   RLIMS-P 21059412
S171 Phosphorylation PhosphoSitePlus   UniProt 23186163
R178 Methylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
R200 Methylation PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
Y387 Phosphorylation PhosphoSitePlus
C393 Methylation IEDB 31844290
K396 Ubiquitination PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
C417 S-Nitrosylation dbSNO 26338901
K477 Acetylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
T525 Phosphorylation PhosphoSitePlus
T527 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation HPRD 19413330, 18669648, 19415658, ...20068231, 18452278
S27 Phosphorylation HPRD 19413330, 18669648, 19415658, ...20068231, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S171 F171 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y248 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T527 P527 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T527 S527 Biomuta DOID:2531 / hematologic cancer [ cosmic ]