iPTMnet Report for O60674 (JAK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60674 / JAK2_HUMAN
Protein Name Tyrosine-protein kinase JAK2
Gene Name Name: JAK2
Organism Homo sapiens (Human)

PRO ID PR:O60674
DAG View
PRO Name tyrosine-protein kinase JAK2 (human)
Definition A tyrosine-protein kinase JAK2 that is encoded in the genome of human.
Short Label hJAK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60674 (JAK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y119 Phosphorylation O60674 (JAK2) PhosphoSitePlus   RLIMS-P 21347402, 17024180
K167 Sumoylation PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
Y201 Phosphorylation O60674 (JAK2) HPRD   PhosphoSitePlus 17027227, 7889566
Y206 Phosphorylation O60674 (JAK2) HPRD 17027227
K207 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
Y221 Phosphorylation O60674 (JAK2) HPRD   PhosphoSitePlus   RLIMS-P   Signor 21691275, 15143187, 15143188, ...33669634
K244 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
Y317 Phosphorylation O60674 (JAK2) RLIMS-P   Signor 19364823, 28676638
S358 Phosphorylation PhosphoSitePlus
Y372 Phosphorylation RLIMS-P 21726629
Y373 Phosphorylation RLIMS-P 21726629
Y382 Phosphorylation PhosphoSitePlus
Y423 Phosphorylation PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus
S473 Phosphorylation RLIMS-P 26919105
S518 Phosphorylation PhosphoSitePlus
T522 Phosphorylation PhosphoSitePlus
S523 Phosphorylation P27361 (MAPK3) , O60674 (JAK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 16705160, 16705159, 23863170, ...21841788
Y570 Phosphorylation O60674 (JAK2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17389395, 23186163, 30108215, ...16464493, 15143187, 18491316, 23863170, 21841788, 15143188
K581 Ubiquitination PhosphoSitePlus
K630 Sumoylation PhosphoSitePlus
Y637 Phosphorylation O60674 (JAK2) PhosphoSitePlus   RLIMS-P   Signor 19364823, 28676638
K728 Ubiquitination PhosphoSitePlus
K762 Ubiquitination PhosphoSitePlus
Y790 Phosphorylation PhosphoSitePlus
Y813 Phosphorylation O60674 (JAK2) HPRD   IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 17565041, 15767667, 15121872
Y868 Phosphorylation O60674 (JAK2) PRO   RLIMS-P   Signor 20304997
K882 Ubiquitination PhosphoSitePlus
K883 Ubiquitination PhosphoSitePlus
K903 Ubiquitination PhosphoSitePlus
S904 Phosphorylation PhosphoSitePlus
K912 Sumoylation PhosphoSitePlus
K914 Sumoylation PhosphoSitePlus
Y931 Phosphorylation PhosphoSitePlus
Y934 Phosphorylation PhosphoSitePlus
S936 Phosphorylation PhosphoSitePlus
Y940 Phosphorylation PhosphoSitePlus
Y956 Phosphorylation PhosphoSitePlus
Y966 Phosphorylation O60674 (JAK2) PRO   PhosphoSitePlus   RLIMS-P   Signor 20304997
K970 Ubiquitination PhosphoSitePlus
Y972 Phosphorylation O60674 (JAK2) PRO   PhosphoSitePlus   RLIMS-P   Signor 18636744, 20304997
K991 Sumoylation PhosphoSitePlus
K999 Ubiquitination PhosphoSitePlus
Y1007 Phosphorylation P40189 (IL6ST) , P00519 (ABL1) , O60674 (JAK2) HPRD   IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24886434, 10421843, 16174768, ...21992896, 21726629, 15143187, 21806020, 22087308, 11593427, 28094778, 11971965, 22359610, 26949510, 23313376, 22284190, 9716487, 21625597, 26413812, 18612371, 28686728, 33898322, 9111318, 22522613, 14522994, 30498775, 31323961, 27029346, 22622019, 21789226, 21388555
Y1008 N-Phosphorylation IntAct 24255956
Y1008 Phosphorylation O60674 (JAK2) , P40189 (IL6ST) HPRD   IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24886434, 16174768, 21992896, ...11593427, 28094778, 28686728, 26949510, 22284190, 9716487, 11818507, 21625597, 32391256, 18612371, 26413812, 9111318, 21806020, 22522613, 30498775, 31323961, 27029346, 21789226, 21388555
K1011 Sumoylation PhosphoSitePlus
K1011 Ubiquitination PhosphoSitePlus
K1069 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y1007 Phosphorylation PRO 19019674
Y1008 Phosphorylation PRO 19019674


O60674 (JAK2) as PTM Enzyme



Substrate Site Score Source PMID
O14543 (SOCS3) Y204 PhosphoSitePlus 12783885
O14543 (SOCS3) Y221 PhosphoSitePlus 12783885
O14744 (PRMT5) Y297 PhosphoSitePlus   Signor 21316606
O14744 (PRMT5) Y304 PhosphoSitePlus 21316606
O14744 (PRMT5) Y307 PhosphoSitePlus 21316606
O60674 (JAK2) Y119 PhosphoSitePlus 17024180
O60674 (JAK2) Y201 HPRD 17027227, 7889566
O60674 (JAK2) Y206 HPRD 17027227
O60674 (JAK2) Y221 HPRD   Signor 15143187, 15143188
O60674 (JAK2) Y317 Signor 19364823
O60674 (JAK2) S523 PhosphoSitePlus   Signor 21841788
O60674 (JAK2) Y570 HPRD   PhosphoSitePlus   Signor 21841788, 15143187, 17389395, ...15143188, 18491316
O60674 (JAK2) Y637 Signor 19364823
O60674 (JAK2) Y813 HPRD   Signor 15121872
O60674 (JAK2) Y868 Signor 20304997
O60674 (JAK2) Y966 Signor 20304997
O60674 (JAK2) Y972 Signor 20304997
O60674 (JAK2) Y1007 HPRD   phospho.ELM   UniProt 11593427, 15143187, 9111318, ...16174768
O60674 (JAK2) Y1008 HPRD   phospho.ELM   UniProt 11818507, 9111318, 16174768
P00533-1 (EGFR) Y1069 HPRD 17016520, 18691976, 17389395, ...9363897, 18669648, 16799092, 10635327
P00533 (EGFR) Y1092 neXtProt 9363897
P04049-1 (RAF1) Y340 HPRD 9689060, 8876196, 11134016
P04049-1 (RAF1) Y341 HPRD 8876196, 10205168
P10912 (GHR) Y332 phospho.ELM 9121492
P10912 (GHR) Y487 phospho.ELM 9121492
P16410 (CTLA4) Y201 HPRD   phospho.ELM   Signor 10842319
P19235 (EPOR) Y368 HPRD   phospho.ELM 12441334, 10579919
P19235-1 (EPOR) Y426 HPRD 12441334
P19235-1 (EPOR) Y454 HPRD 12441334
P19235-1 (EPOR) Y456 HPRD 12441334
P19235-1 (EPOR) Y468 HPRD 12441334
P19235-1 (EPOR) Y485 HPRD 12441334
P19235-1 (EPOR) Y489 HPRD 12441334
P19235-1 (EPOR) Y504 HPRD 12441334
P27361 (MAPK3) Y204 PhosphoSitePlus 16464493
P28482 (MAPK1) Y187 PhosphoSitePlus 16464493
P40763-2 (STAT3) Y704 HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
P40763 (STAT3) Y705 HPRD   phospho.ELM   PhosphoSitePlus   Signor 17016520, 19901323, 10918587, ...12626508, 12576423, 8626374, 9575217, 11350938, 16464493, 14551213, 17389395, 9582023, 11294897, 11940572, 12244095, 16497976
P41597 (CCR2) Y139 phospho.ELM   PhosphoSitePlus   Signor 9670957
P42224 (STAT1) Y701 HPRD   phospho.ELM   PhosphoSitePlus   Signor 11839738, 10918587, 7657660, ...15322115, 7543024, 16464493, 11438544, 12817007, 11152457, 7690989, 11294897, 12637327, 14978237
P42229 (STAT5A) Y694 HPRD   phospho.ELM   PhosphoSitePlus 17016520, 17389395, 11413148, ...16464493, 7925280, 11641791, 8617237, 16497976
P42680 (TEC) Y519 neXtProt 9473212
P46527 (CDKN1B) Y88 neXtProt 21423214
P48357 (LEPR) Y986 Signor 11018044
P48357 (LEPR) Y1141 Signor 11018044
P51692 (STAT5B) Y699 neXtProt 12456798
P62993 (GRB2) Y7 PhosphoSitePlus 19273609
P62993 (GRB2) Y37 PhosphoSitePlus 19273609
P62993 (GRB2) Y52 PhosphoSitePlus 19273609
P62993 (GRB2) Y209 PhosphoSitePlus 19273609
P78324-1 (SIRPA) Y496 HPRD 10842184, 17016520, 17389395
P78347-3 (GTF2I) Y248 HPRD   neXtProt   PhosphoSitePlus 9012831, 9837922, 11313464, ...11373296, 11934902
P84243 (H3-3B) Y42 neXtProt 19783980
Q13153 (PAK1) Y153 neXtProt   PhosphoSitePlus   RLIMS-P+ 25466889, 17726028
Q13153 (PAK1) Y201 neXtProt   PhosphoSitePlus   RLIMS-P+ 25466889, 17726028
Q13153 (PAK1) Y285 neXtProt   PhosphoSitePlus   RLIMS-P+ 25466889, 17726028
Q14765 (STAT4) Y693 Signor 16324152
Q15118 (PDK1) Y243 neXtProt   PhosphoSitePlus 22195962
Q15910 (EZH2) Y641 PhosphoSitePlus   Signor 24469040
Q92858 (ATOH1) Y80 Signor 29168692
Q92888 (ARHGEF1) Y738 neXtProt   PhosphoSitePlus   Signor 20098430
Q99683 (MAP3K5) Y718 neXtProt   PhosphoSitePlus   Signor 19287004
Q9UGK3 (STAP2) Y22 neXtProt   PhosphoSitePlus 12540842
Q9UGK3-2 (STAP2) Y250 HPRD   PhosphoSitePlus 12540842
Q9UGK3 (STAP2) Y310 HPRD   neXtProt   PhosphoSitePlus 12540842
Q9UGK3 (STAP2) Y322 neXtProt   PhosphoSitePlus 12540842
Q9UQC2 (GAB2) Y643 neXtProt   PhosphoSitePlus   Signor 18644434


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048085 (hJAK2/Phos:2) pY1007 PRO
PR:000048086 (hJAK2/Phos:3) pY813 PRO
PR:000048087 (hJAK2/Phos:4) pY813,pY868,pY966,pY972,pY1008 PRO
PR:000025747 (hJAK2/iso:1/Phos:1) pY1007,pY1008 PRO 19019674