iPTMnet Report for O60658 (PDE8A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60658 / PDE8A_HUMAN
Protein Name High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Gene Name Name: PDE8A
Organism Homo sapiens (Human)

PRO ID PR:O60658
DAG View
PRO Name high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human)
Definition A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A that is encoded in the genome of human.
Short Label hPDE8A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60658 (PDE8A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163
T39 Phosphorylation PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
Y290 Phosphorylation PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22673573
K363 Ubiquitination PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
T370 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
S386 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S407 Phosphorylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
Y428 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
S457 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...20068231
Y461 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
K686 Ubiquitination PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
C731 Methylation IEDB 31844290
T752 Phosphorylation PhosphoSitePlus
K820 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation HPRD 18691976, 20068231
S386 Phosphorylation HPRD 18669648, 18212344
S407 Phosphorylation HPRD 18691976, 20068231
S457 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S464 Phosphorylation HPRD 17081983
T465 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation HPRD 18691976, 20068231
S340 Phosphorylation HPRD 18669648, 18212344
S361 Phosphorylation HPRD 18691976, 20068231
S411 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S418 Phosphorylation HPRD 17081983
T419 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S153 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K284 N284 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y319 H319 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S373 C373 Biomuta DOID:1612 / breast cancer [ cosmic ]
T419 K419 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S429 P429 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S429 L429 Biomuta DOID:4159 / skin cancer [ cosmic ]
T465 K465 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K820 M820 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]