iPTMnet Report for O60645 (EXOC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60645 / EXOC3_HUMAN
Protein Name Exocyst complex component 3
Gene Name Name: EXOC3
Synonyms:SEC6,SEC6L1;
Organism Homo sapiens (Human)

PRO ID PR:O60645
DAG View
PRO Name exocyst complex component 3 (human)
Definition An exocyst complex component 3 that is encoded in the genome of human.
Short Label hEXOC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60645 (EXOC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K28 Acetylation PhosphoSitePlus   UniProt 19608861
K28 Ubiquitination PhosphoSitePlus
K48 Methylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
T201 Phosphorylation HPRD   PhosphoSitePlus 19664995
K221 Acetylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
S338 Phosphorylation IEDB 35494241
C485 Methylation IEDB 31844290
C497 Methylation IEDB 31844290
K508 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
Y726 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T201 I201 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K221 N221 Biomuta DOID:1324 / lung cancer [ cosmic ]
K231 R231 Biomuta DOID:10534 / stomach cancer [ cosmic ]
C485 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K708 M708 Biomuta DOID:10534 / stomach cancer [ icgc ]
S723 N723 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]