iPTMnet Report for O60602 (TLR5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60602 / TLR5_HUMAN
Protein Name Toll-like receptor 5 precursor
Gene Name Name: TLR5
Synonyms:TIL3;
Organism Homo sapiens (Human)

PRO ID PR:O60602
DAG View
PRO Name Toll-like receptor 5 (human)
Definition A Toll-like receptor 5 that is encoded in the genome of human.
Short Label hTLR5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60602 (TLR5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N37 N-Glycosylation GlyGen   UniProt 22173220
N46 N-Glycosylation GlyGen   UniProt 22173220
Y108 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
N245 N-Glycosylation GlyGen   UniProt 22173220
N342 N-Glycosylation GlyGen   UniProt 22173220
N422 N-Glycosylation GlyGen   UniProt 22173220
N595 N-Glycosylation GlyGen   UniProt 22173220
N598 N-Glycosylation GlyGen   UniProt 22173220
K680 Acetylation PhosphoSitePlus
Y798 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 17157808
S805 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20557879, 17442957
S805 Phosphorylation Q15139 (PRKD1) neXtProt   PhosphoSitePlus   Signor 20557879, 17442957


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N37 S37 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y108 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
N342 T342 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
N342 H342 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K680 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S805 F805 Biomuta DOID:4159 / skin cancer [ cosmic ]