iPTMnet Report for O60583 (CCNT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60583 / CCNT2_HUMAN
Protein Name Cyclin-T2
Gene Name Name: CCNT2
Organism Homo sapiens (Human)

PRO ID PR:O60583
DAG View
PRO Name cyclin-T2 (human)
Definition A cyclin-T2 that is encoded in the genome of human.
Short Label hCCNT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60583 (CCNT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
C122 Methylation IEDB 31844290
K407 Sumoylation PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
T479 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S480 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 21406692, 15302935
K485 Ubiquitination PhosphoSitePlus
K493 Acetylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
K520 Acetylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
T597 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19690332, 19369195
S617 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T479 Phosphorylation HPRD 18669648, 20068231
S480 Phosphorylation HPRD 19413330, 18691976, 18767875, ...19664994, 19664995, 17322306, 19651622
S548 Phosphorylation HPRD 18691976
S549 Phosphorylation HPRD 18691976, 20068231
S582 Phosphorylation HPRD 18691976
S590 Phosphorylation HPRD 19664994
T597 Phosphorylation HPRD 18691976, 19664994
S601 Phosphorylation HPRD 18691976, 19664994, 18452278
Site PTM Type PTM Enzyme Score Source PMID
T479 Phosphorylation HPRD 18669648, 20068231
S480 Phosphorylation HPRD 19413330, 18691976, 18767875, ...19664994, 19664995, 17322306, 19651622
S548 Phosphorylation HPRD 18691976
S549 Phosphorylation HPRD 18691976, 20068231
S582 Phosphorylation HPRD 18691976
S590 Phosphorylation HPRD 19664994
T597 Phosphorylation HPRD 18691976, 19664994
S601 Phosphorylation HPRD 18691976, 19664994, 18452278
S638 Phosphorylation HPRD 20068231
S640 Phosphorylation HPRD 20068231
R662 Methylation PhosphoSitePlus
S663 Phosphorylation HPRD   PhosphoSitePlus 18691976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S480 Y480 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ icgc ]
S480 F480 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K520 N520 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S538 F538 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S549 R549 Biomuta DOID:3571 / liver cancer [ cosmic ]
S582 G582 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T597 S597 Biomuta DOID:1324 / lung cancer [ cosmic ]
S617 L617 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S638 F638 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S640 R640 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S645 F645 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ icgc, cosmic, icgc ] DOID:363 / uterine cancer [ icgc ]
R662 W662 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ icgc ]