iPTMnet Report for O60547 (GMDS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60547 / GMDS_HUMAN
Protein Name GDP-mannose 4,6 dehydratase
Gene Name Name: GMDS
Organism Homo sapiens (Human)

PRO ID PR:O60547
DAG View
PRO Name GDP-mannose 4,6 dehydratase (human)
Definition A GDP-mannose 4,6 dehydratase that is encoded in the genome of human.
Short Label hGMDS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60547 (GMDS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S10 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
Y69 Phosphorylation PhosphoSitePlus
K70 Acetylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
Y231 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K322 Acetylation PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y324 Phosphorylation PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 19413330
S14 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S14 C14 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S59 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K140 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K149 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K149 M149 Biomuta DOID:1324 / lung cancer [ cosmic ]
K161 N161 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K322 * Biomuta DOID:10534 / stomach cancer [ cosmic ]