iPTMnet Report for O60508 (CDC40)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60508 / PRP17_HUMAN
Protein Name Pre-mRNA-processing factor 17
Gene Name Name: CDC40
Synonyms:EHB3,PRP17,PRPF17;
Organism Homo sapiens (Human)

PRO ID PR:O60508
DAG View
PRO Name pre-mRNA-processing factor 17 (human)
Definition A pre-mRNA-processing factor 17 that is encoded in the genome of human.
Short Label hCDC40
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60508 (CDC40) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
Y12 Phosphorylation HPRD 17081983, 20068231
S14 Phosphorylation HPRD 17081983, 20068231
S16 Phosphorylation HPRD   PhosphoSitePlus 17081983
S18 Phosphorylation HPRD 17081983, 20068231
S20 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S22 Phosphorylation HPRD 17081983, 20068231
S24 Phosphorylation HPRD 17081983, 20068231
S27 Phosphorylation HPRD 17081983, 20068231
S43 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S45 Phosphorylation PhosphoSitePlus
S46 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S49 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S56 Phosphorylation PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus
Y85 Phosphorylation PhosphoSitePlus
Y114 Phosphorylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K226 Acetylation PhosphoSitePlus
K228 Acetylation PhosphoSitePlus
C366 Methylation IEDB 31844290
C378 Methylation IEDB 31844290
K380 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K399 Acetylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y12 C12 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y85 C85 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y114 D114 Biomuta DOID:10534 / stomach cancer [ cosmic ]