iPTMnet Report for O60503 (ADCY9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60503 / ADCY9_HUMAN
Protein Name Adenylate cyclase type 9
Gene Name Name: ADCY9
Synonyms:KIAA0520;
Organism Homo sapiens (Human)

PRO ID PR:O60503
DAG View
PRO Name adenylate cyclase type 9 (human)
Definition An adenylate cyclase type 9 that is encoded in the genome of human.
Short Label hADCY9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60503 (ADCY9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
N206 N-Glycosylation GlyGen 24190977
S316 Phosphorylation IEDB 35494241
K321 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K330 Acetylation PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
S354 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S357 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T363 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S365 Phosphorylation HPRD   PhosphoSitePlus 17081983
K377 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
T494 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
T608 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
S632 Phosphorylation PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
S688 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
S706 Phosphorylation PhosphoSitePlus   UniProt 24275569
K723 Ubiquitination PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
N964 N-Glycosylation GlyGen 24190977
K1098 Ubiquitination PhosphoSitePlus
T1109 Phosphorylation PhosphoSitePlus
S1212 Phosphorylation PhosphoSitePlus
S1217 Phosphorylation PhosphoSitePlus
K1218 Ubiquitination PhosphoSitePlus
Y1221 Phosphorylation PhosphoSitePlus
Y1225 Phosphorylation PhosphoSitePlus
S1257 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S1259 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
S1269 Phosphorylation PhosphoSitePlus
K1302 Ubiquitination PhosphoSitePlus
S1307 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K1330 Ubiquitination PhosphoSitePlus
K1346 Ubiquitination PhosphoSitePlus
S1350 Phosphorylation PhosphoSitePlus
S1352 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K35 R35 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y122 C122 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y133 S133 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y133 C133 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:5158 / pleural cancer [ cosmic ]
K327 T327 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K327 Q327 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K480 M480 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K537 N537 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K564 Q564 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S610 P610 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S632 L632 Biomuta DOID:4159 / skin cancer [ cosmic ]
K699 E699 Biomuta DOID:3571 / liver cancer [ cosmic ]
K773 N773 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S1259 F1259 Biomuta DOID:4159 / skin cancer [ cosmic ]