Protein Information

Cytoscape View


UniProt AC / UniProt ID O60500 / NPHN_HUMAN
Protein Name Nephrin precursor
Gene Name Name: NPHS1
Synonyms:NPHN;
Organism Homo sapiens (Human)

PRO ID PR:O60500
DAG View
PRO Name nephrin (human)
Definition A nephrin that is encoded in the genome of human.
Short Label hNPHS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60500 (NPHS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T414 Phosphorylation PhosphoSitePlus
T416 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
S432 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087
Y439 Phosphorylation PhosphoSitePlus
Y638 Phosphorylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
T710 Phosphorylation PhosphoSitePlus
T1120 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 21321125
T1125 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 21321125
Y1176 Phosphorylation PhosphoSitePlus   RLIMS-P 22718751, 25321392
Y1193 Phosphorylation P06241 (FYN) neXtProt   PhosphoSitePlus   RLIMS-P 16968782, 19179337, 25321392, ...22718751
Y1217 Phosphorylation PhosphoSitePlus   RLIMS-P 22718751, 30212551, 24995775, ...25321392
Site PTM Type PTM Enzyme Score Source PMID
S432 Phosphorylation HPRD 18088087


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O60500 (NPHS1) Y1193 Q9NP85 (NPHS2) inhibited_association eFIP 32020343


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S432 * Biomuta DOID:1324 / lung cancer [ tcga ]
T710 S710 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y1176 C1176 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y1193 * Biomuta DOID:3571 / liver cancer [ icgc ]