iPTMnet Report for O60496 (DOK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60496 / DOK2_HUMAN
Protein Name Docking protein 2
Gene Name Name: DOK2
Organism Homo sapiens (Human)

PRO ID PR:O60496
DAG View
PRO Name docking protein 2 (human)
Definition A docking protein 2 that is encoded in the genome of human.
Short Label hDOK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60496 (DOK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Ubiquitination PhosphoSitePlus
Y12 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16497976
S140 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
Y170 Phosphorylation PhosphoSitePlus
T189 Phosphorylation PhosphoSitePlus
Y192 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
Y271 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 10428862, 10508618
Y271 Phosphorylation P07948 (LYN) HPRD 10428862
Y271 Phosphorylation P08631 (HCK) HPRD 10428862
Y271 Phosphorylation P12931 (SRC) HPRD 10428862
S277 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
Y299 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19901323, 23186163, 16094384, ...15144186, 10508618, 18083107, 12522270, 15592455, 10428862, 19690332, 16497976
Y299 Phosphorylation P07948 (LYN) HPRD 19901323, 10428862, 16497976
Y299 Phosphorylation P08631 (HCK) HPRD 19901323, 10428862, 16497976
Y299 Phosphorylation P12931 (SRC) HPRD 19901323, 10428862, 16497976
S309 Phosphorylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
Y330 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation HPRD   IntAct   phospho.ELM   PhosphoSitePlus 11689432, 10428862, 9764820
Y345 Phosphorylation P07948 (LYN) HPRD 10428862
Y345 Phosphorylation P08631 (HCK) HPRD 10428862
Y345 Phosphorylation P12931 (SRC) HPRD 10428862
Y357 Phosphorylation PhosphoSitePlus
Y402 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S34 L34 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S129 R129 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S169 P169 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K312 N312 Biomuta DOID:363 / uterine cancer [ icgc ]
S332 N332 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y357 S357 Biomuta DOID:2531 / hematologic cancer [ cosmic ]