iPTMnet Report for O60493 (SNX3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60493 / SNX3_HUMAN
Protein Name Sorting nexin-3
Gene Name Name: SNX3
Organism Homo sapiens (Human)

PRO ID PR:O60493
DAG View
PRO Name sorting nexin-3 (human)
Definition A sorting nexin-3 that is encoded in the genome of human.
Short Label hSNX3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60493 (SNX3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
A2 Acetylation UniProt 19413330, 12665801, 25944712
K14 Ubiquitination PhosphoSitePlus
Y22 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
R43 Methylation PhosphoSitePlus   UniProt 24129315
R45 Methylation PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
T48 Phosphorylation PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
S72 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
S79 Phosphorylation PhosphoSitePlus
K86 Sumoylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K95 Sumoylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K119 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K128 Sumoylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
T155 Phosphorylation PhosphoSitePlus
K158 Sumoylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y71 Phosphorylation HPRD 20068231
S72 Phosphorylation HPRD 16964243, 19651622, 18669648, ...20166139, 20068231, 17081983
S157 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S125 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049316 (hSNX3/InitMet-/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 E2 Biomuta DOID:3571 / liver cancer [ cosmic ]
R43 L43 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R45 L45 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S72 R72 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S79 R79 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]