iPTMnet Report for O60488 (ACSL4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60488 / ACSL4_HUMAN
Protein Name Long-chain-fatty-acid--CoA ligase 4
Gene Name Name: ACSL4
Synonyms:ACS4,FACL4,LACS4;
Organism Homo sapiens (Human)

PRO ID PR:O60488
DAG View
PRO Name long-chain-fatty-acid--CoA ligase 4 (human)
Definition A long-chain-fatty-acid--CoA ligase 4 that is encoded in the genome of human.
Short Label hACSL4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60488 (ACSL4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation PhosphoSitePlus
Y31 Phosphorylation PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
T51 O-Glycosylation GlyGen 33214551, 32357142, 33465208
S52 O-Glycosylation GlyGen 33465208
K54 Ubiquitination PhosphoSitePlus
S57 O-Glycosylation GlyGen 33465208
S57 Phosphorylation PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus
K89 Acetylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K92 Acetylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
C157 Methylation IEDB 31844290
K211 Ubiquitination PhosphoSitePlus
C221 S-Nitrosylation dbSNO 26338901
K223 Ubiquitination PhosphoSitePlus
Y227 Phosphorylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K397 Acetylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K401 Acetylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
Y415 Phosphorylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y483 Phosphorylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
T508 Phosphorylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
Y541 Phosphorylation PhosphoSitePlus
C564 Methylation IEDB 31844290
Y582 Phosphorylation PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
S674 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T679 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T682 Phosphorylation PhosphoSitePlus
T686 Phosphorylation PhosphoSitePlus
K690 Acetylation PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S95 Phosphorylation HPRD 20068231
S140 Phosphorylation HPRD 20068231
S674 Phosphorylation HPRD 18669648
T679 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S54 Phosphorylation HPRD 20068231
S99 Phosphorylation HPRD 20068231
S633 Phosphorylation HPRD 18669648
T638 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K47 N47 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S57 N57 Biomuta [ cosmic ]
K113 R113 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T143 I143 Biomuta DOID:4159 / skin cancer [ cosmic ]
K211 E211 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K312 N312 Biomuta DOID:363 / uterine cancer [ icgc ]
K312 M312 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T485 A485 Biomuta DOID:363 / uterine cancer [ icgc ]
K498 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S584 Y584 Biomuta DOID:363 / uterine cancer [ icgc ]
K593 E593 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K593 N593 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K593 R593 Biomuta DOID:263 / kidney cancer [ cosmic ]
S607 G607 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S607 I607 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K621 Q621 Biomuta DOID:3571 / liver cancer [ cosmic ]
K670 N670 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S674 G674 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]