iPTMnet Report for O60462 (NRP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60462 / NRP2_HUMAN
Protein Name Neuropilin-2 precursor
Gene Name Name: NRP2
Synonyms:VEGF165R2;
Organism Homo sapiens (Human)

PRO ID PR:O60462
DAG View
PRO Name neuropilin-2 (human)
Definition A neuropilin-2 that is encoded in the genome of human.
Short Label hNRP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60462 (NRP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N152 N-Glycosylation GlyGen   UniProt 17989695, 24190977
N157 N-Glycosylation GlyGen   UniProt 17989695, 24190977
T319 Phosphorylation PhosphoSitePlus
T494 Phosphorylation PhosphoSitePlus
R507 Methylation PhosphoSitePlus
T595 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T600 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T603 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T607 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S672 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S673 O-Glycosylation GlyGen 25813380
T679 O-Glycosylation GlyGen 25813380
S781 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S874 Phosphorylation PhosphoSitePlus
S880 Phosphorylation PhosphoSitePlus
Y882 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T319 I319 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
R507 H507 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
R507 C507 Biomuta DOID:1319 / brain cancer [ icgc ]
T595 A595 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T600 A600 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T600 M600 Biomuta DOID:4159 / skin cancer [ cosmic ]
T603 M603 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1319 / brain cancer [ icgc ]
T679 M679 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y882 * Biomuta DOID:1324 / lung cancer [ cosmic ]