iPTMnet Report for O60443 (GSDME)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60443 / GSDME_HUMAN
Protein Name Gasdermin-E
Gene Name Name: GSDME
Synonyms:DFNA5;
Organism Homo sapiens (Human)

PRO ID PR:O60443
DAG View
PRO Name gasdermin-E (human)
Definition A gasdermin-E that is encoded in the genome of human.
Short Label hGSDME
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60443 (GSDME) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Ubiquitination PhosphoSitePlus
T6 Phosphorylation PhosphoSitePlus
Y80 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
T117 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
C156 Methylation IEDB 31844290
C156 S-Nitrosylation dbSNO 20140087, 22178444
K248 Ubiquitination PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
Y254 Phosphorylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
C417 Methylation IEDB 31844290
K440 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
C482 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S252 Phosphorylation HPRD 20068231
Y254 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K83 N83 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S132 C132 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S252 F252 Biomuta DOID:9256 / colorectal cancer [ cosmic ]