iPTMnet Report for O60437 (PPL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60437 / PEPL_HUMAN
Protein Name Periplakin
Gene Name Name: PPL
Synonyms:KIAA0568;
Organism Homo sapiens (Human)

PRO ID PR:O60437
DAG View
PRO Name periplakin (human)
Definition A periplakin that is encoded in the genome of human.
Short Label hPPL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60437 (PPL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K12 Acetylation PhosphoSitePlus
Y13 Phosphorylation PhosphoSitePlus
S14 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692, 23186163, ...19691289
T16 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K130 Acetylation PhosphoSitePlus
Y198 Phosphorylation IEDB 35494241
S205 Phosphorylation PhosphoSitePlus
Y218 Phosphorylation PhosphoSitePlus
Y227 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
Y255 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y488 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
T553 O-Glycosylation GlyGen 36240223, 35138101
T583 Phosphorylation PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
S644 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
Y732 Phosphorylation PhosphoSitePlus
S779 Phosphorylation HPRD   PhosphoSitePlus 19664995
S830 Phosphorylation PhosphoSitePlus
Y850 Phosphorylation PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus   UniProt 21406692
S931 Phosphorylation PhosphoSitePlus
S949 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y992 Phosphorylation PhosphoSitePlus
Y1070 Phosphorylation PhosphoSitePlus
K1143 Ubiquitination PhosphoSitePlus
S1214 Phosphorylation PhosphoSitePlus
K1229 Acetylation PhosphoSitePlus
K1258 Ubiquitination PhosphoSitePlus
Y1270 Phosphorylation PhosphoSitePlus
K1273 Acetylation PhosphoSitePlus
K1274 Acetylation PhosphoSitePlus
K1280 Acetylation PhosphoSitePlus
S1331 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935
Y1358 Phosphorylation PhosphoSitePlus
T1397 Phosphorylation PhosphoSitePlus
S1521 Phosphorylation PhosphoSitePlus
S1538 Phosphorylation PhosphoSitePlus
S1552 Phosphorylation PhosphoSitePlus
T1579 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16565220
S1584 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1610 Phosphorylation PhosphoSitePlus
S1614 Phosphorylation PhosphoSitePlus
K1623 Acetylation PhosphoSitePlus
S1642 Phosphorylation PhosphoSitePlus
K1646 Sumoylation PhosphoSitePlus
S1657 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 19691289, ...24275569
T1665 Phosphorylation PhosphoSitePlus
S1670 Phosphorylation PhosphoSitePlus
K1718 Acetylation PhosphoSitePlus
S1744 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S465 I465 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S465 T465 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S465 R465 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K513 R513 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y732 F732 Biomuta [ cosmic ]
Y732 C732 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y732 N732 Biomuta [ cosmic ]
Y850 F850 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S887 P887 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S931 L931 Biomuta DOID:363 / uterine cancer [ icgc ]
S1331 F1331 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1584 L1584 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S1670 Y1670 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1744 F1744 Biomuta DOID:4362 / cervical cancer [ cosmic ]