Protein Information

Cytoscape View

UniProt AC / UniProt ID O60353 / FZD6_HUMAN
Protein Name Frizzled-6 precursor
Gene Name Name: FZD6
Organism Homo sapiens (Human)

PRO ID PR:O60353
DAG View
PRO Name frizzled-6 (human)
Definition A frizzled-6 that is encoded in the genome of human.
Short Label hFZD6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O60353 (FZD6) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
T5 Phosphorylation PhosphoSitePlus
N38 N-Glycosylation GlyGen 29671580
K108 Ubiquitination PhosphoSitePlus
T136 O-Glycosylation GlyGen 30459171
T141 O-Glycosylation GlyGen 30459171
K148 Ubiquitination PhosphoSitePlus
T150 O-Glycosylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
T213 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
K532 Methylation PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
S606 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T607 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
C615 S-Nitrosylation dbSNO 26338901
S620 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
S626 Phosphorylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus   RLIMS-P 30309985
S653 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S656 Phosphorylation phospho.ELM 18669648
T659 Phosphorylation phospho.ELM 18669648
T661 Phosphorylation PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S606 Phosphorylation HPRD 18669648
T607 Phosphorylation HPRD 18669648
S653 Phosphorylation HPRD 18669648
S656 Phosphorylation HPRD 18669648
T659 Phosphorylation HPRD 18669648


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047477 (hFZD6/SigPep-/UbiqLys+) ub PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T150 I150 Biomuta DOID:3070 / malignant glioma [ tcga ]
S496 T496 Biomuta DOID:1324 / lung cancer [ tcga ]
T607 P607 Biomuta DOID:4159 / skin cancer [ icgc ]
S626 C626 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S629 F629 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
T661 A661 Biomuta DOID:9256 / colorectal cancer [ tcga ]