iPTMnet Report for O60346 (PHLPP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60346 / PHLP1_HUMAN
Protein Name PH domain leucine-rich repeat-containing protein phosphatase 1
Gene Name Name: PHLPP1
Synonyms:KIAA0606,PHLPP,PLEKHE1,SCOP;
Organism Homo sapiens (Human)

PRO ID PR:O60346
DAG View
PRO Name PH domain leucine-rich repeat-containing protein phosphatase 1 (human)
Definition A PH domain leucine-rich repeat-containing protein phosphatase that is encoded in the genome of human.
Short Label hPHLPP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60346 (PHLPP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S50 Phosphorylation PhosphoSitePlus
T56 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
T222 O-Glycosylation GlyGen 30459171
K240 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus   UniProt 23186163
S321 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
T409 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus   UniProt 23186163
S425 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
T451 Phosphorylation PhosphoSitePlus
T797 O-Glycosylation GlyGen 30379171
K1071 Ubiquitination PhosphoSitePlus
K1146 Ubiquitination PhosphoSitePlus
T1147 O-Glycosylation GlyGen 30379171
K1323 Ubiquitination PhosphoSitePlus
S1359 Phosphorylation PhosphoSitePlus   Signor 19797085
S1359 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus 19797085
S1359 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 19797085
T1363 Phosphorylation PhosphoSitePlus 19797085
T1363 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus 19797085
T1363 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 19797085
S1379 Phosphorylation PhosphoSitePlus 19797085
S1379 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus 19797085
S1379 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 19797085
S1381 Phosphorylation PhosphoSitePlus 19797085
S1381 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus 19797085
S1381 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 19797085
K1400 Ubiquitination PhosphoSitePlus
S1526 Phosphorylation PhosphoSitePlus
T1617 Phosphorylation PhosphoSitePlus
Y1712 Phosphorylation PhosphoSitePlus
Y1713 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S323 P323 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S450 F450 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1146 T1146 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1359 F1359 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S1526 F1526 Biomuta DOID:4159 / skin cancer [ cosmic ]