Protein Information

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UniProt AC / UniProt ID O60343 / TBCD4_HUMAN
Protein Name TBC1 domain family member 4
Gene Name Name: TBC1D4
Synonyms:AS160,KIAA0603;
Organism Homo sapiens (Human)

PRO ID PR:O60343
DAG View
PRO Name TBC1 domain family member 4 (human)
Definition A TBC1 domain family member 4 that is encoded in the genome of human.
Short Label hTBC1D4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60343 (TBC1D4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S44 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus   UniProt 24275569
T274 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus   UniProt 23186163
S317 Phosphorylation PhosphoSitePlus
S318 Phosphorylation O00141 (SGK1) , P31749 (AKT1) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P 26465605, 20938636, 19252894, ...12637568, 20410134, 17617058, 23801578, 25103239
T320 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S341 Phosphorylation Q15418 (RPS6KA1) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 30135087, 21406692, 17287340, ...12637568, 24876356, 19252894, 17617058, 18669648, 24247980, 17995453, 23186163, 22851577, 20068231
S344 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 17081983
S349 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
T356 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K477 Acetylation PhosphoSitePlus   UniProt 19608861
S485 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
S486 Phosphorylation PhosphoSitePlus
T488 Phosphorylation PhosphoSitePlus
S551 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
K555 Ubiquitination PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
S566 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...19690332, 20068231
T568 Phosphorylation O00141 (SGK1) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 23186163, 20410134, 17617058, ...18669648, 19690332
S569 Phosphorylation PhosphoSitePlus
S570 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 12637568, 18220336, ...17617058, 18669648, 19690332
S576 Phosphorylation PhosphoSitePlus
R577 Methylation PhosphoSitePlus
S588 Phosphorylation O14757 (CHEK1) , P31749 (AKT1) , O00141 (SGK1) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 24876356, 26465605, 16964243, ...21406692, 23186163, 23801578, 11994271, 24275569, 19690332, 25103239, 18220336, 20938636, 17617058, 24843827, 16083285, 19252894, 17081983, 20410134, 18669648, 21851590, 22851577, 20068231
S591 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 24275569
S595 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
T613 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
T642 Phosphorylation O00141 (SGK1) , P31749 (AKT1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 24876356, 26465605, 31034517, ...20574165, 17995453, 19013499, 23752133, 23801578, 11994271, 25991826, 16880201, 25103239, 12637568, 17617058, 18771725, 28487439, 21505451, 30872638, 24843827, 22207758, 20410134, 18801932, 25280670
S644 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
S666 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 17617058, ...23801578
S672 Phosphorylation phospho.ELM 18669648
S673 Phosphorylation phospho.ELM 18669648
S678 Phosphorylation phospho.ELM 18669648
T701 Phosphorylation PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus   RLIMS-P 24876356, 28487439, 24247980
S707 Phosphorylation PhosphoSitePlus
T749 Phosphorylation PhosphoSitePlus
S750 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S751 Phosphorylation O00141 (SGK1) , Q15418 (RPS6KA1) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P 20410134, 19252894, 12637568, ...20938636, 17617058, 23801578, 18669648, 25103239
T752 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S754 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935, ...17081983
S757 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S759 Phosphorylation PhosphoSitePlus
T763 Phosphorylation PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus
T766 Phosphorylation PhosphoSitePlus
S782 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
S806 Phosphorylation PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus
Y1191 Phosphorylation PhosphoSitePlus
S1207 Phosphorylation PhosphoSitePlus
S1246 Phosphorylation PhosphoSitePlus
K1255 Ubiquitination PhosphoSitePlus
K1267 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S341 Phosphorylation HPRD 17322306, 17287340, 18212344, ...18767875, 19664995, 19651622, 18669648, 20166139, 20068231
S344 Phosphorylation HPRD 19651622, 18767875, 18669648, ...17081983
S566 Phosphorylation HPRD 18669648, 20068231
T568 Phosphorylation HPRD 18669648
S569 Phosphorylation HPRD 19664995
S570 Phosphorylation HPRD 17322306, 19413330, 18669648, ...19664995, 17693683
S588 Phosphorylation HPRD 19413330, 16083285, 16964243, ...18767875, 19664994, 19664995, 18452278, 18669648, 20068231, 18212344
S591 Phosphorylation HPRD 19413330, 18669648, 19664994, ...16964243, 19664995
S666 Phosphorylation HPRD 17322306, 19651622, 18669648
T749 Phosphorylation HPRD 19413330, 17081983
S750 Phosphorylation HPRD 18669648, 17081983
S751 Phosphorylation HPRD 19413330, 18669648, 17081983
T752 Phosphorylation HPRD 19413330, 18669648, 17081983
S754 Phosphorylation HPRD 19413330, 18669648, 15302935
S757 Phosphorylation HPRD 18669648
S759 Phosphorylation HPRD 17081983
T766 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S666 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S725 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049404 (hTBC1D4/Phos:1) pS318,pS341,pS570,pS588,pT642,pS751 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S66 N66 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S102 W102 Biomuta DOID:1324 / lung cancer [ cosmic ]
S102 P102 Biomuta DOID:363 / uterine cancer [ tcga ]
S262 F262 Biomuta DOID:1909 / melanoma [ tcga ]
S344 C344 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S486 A486 Biomuta DOID:363 / uterine cancer [ tcga ]
R577 K577 Biomuta DOID:363 / uterine cancer [ tcga ]
S609 F609 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S633 F633 Biomuta DOID:1909 / melanoma [ tcga ]
S704 F704 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S787 A787 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S1246 Y1246 Biomuta DOID:363 / uterine cancer [ tcga ]
K1255 R1255 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]