Protein Information

Cytoscape View


UniProt AC / UniProt ID O60341 / KDM1A_HUMAN
Protein Name Lysine-specific histone demethylase 1A
Gene Name Name: KDM1A
Synonyms:AOF2,KDM1,KIAA0601,LSD1;
Organism Homo sapiens (Human)

PRO ID PR:O60341
DAG View
PRO Name lysine-specific histone demethylase 1A (human)
Definition A lysine-specific histone demethylase 1A that is encoded in the genome of human.
Short Label hKDM1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60341 (KDM1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
T59 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 32494624
S69 Phosphorylation PhosphoSitePlus
S80 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T99 Phosphorylation PhosphoSitePlus
T104 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
T110 Phosphorylation RLIMS-P 27325688
S111 Phosphorylation PhosphoSitePlus   RLIMS-P 29311580, 32612611, 27325688
K114 Methylation PhosphoSitePlus
K117 Sumoylation PhosphoSitePlus
S126 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28344766, 18669648, 17081983, ...24275569
S131 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 23186163, ...17081983, 19369195, 28344766, 15302935, 18669648, 25999347, 24275569, 31900384, 19690332, 20068231
Y135 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
Y136 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S137 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 25999347, 24275569, 19690332, 20068231
S166 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...18220336, 15302935, 18669648, 20068231, 25999347
S172 Phosphorylation PhosphoSitePlus
R187 Methylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
K322 Methylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
Y363 Phosphorylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
K424 Sumoylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K432 Acetylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K433 Acetylation PhosphoSitePlus
K436 Acetylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K442 Sumoylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K452 Sumoylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus   UniProt 25018020
K507 Ubiquitination PhosphoSitePlus
K585 Sumoylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
T588 Phosphorylation PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus   UniProt 23186163
K617 Ubiquitination PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
S683 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P+ 27501329
S687 Phosphorylation PhosphoSitePlus   RLIMS-P 27501329
K732 Ubiquitination PhosphoSitePlus
K744 Ubiquitination PhosphoSitePlus
R838 Methylation PhosphoSitePlus
T841 Phosphorylation PhosphoSitePlus
S849 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S851 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T59 Phosphorylation HPRD 18669648
S80 Phosphorylation HPRD 18669648
T88 Phosphorylation HPRD 17081983
T104 Phosphorylation HPRD 18669648
S126 Phosphorylation HPRD 18669648, 17081983, 19415658
S131 Phosphorylation HPRD 19413330, 18691976, 15302935, ...19664995, 18452278, 19651622, 18669648, 19415658, 20068231
Y135 Phosphorylation HPRD 19413330, 18669648, 19664995, ...18452278
Y136 Phosphorylation HPRD 19413330, 18669648, 19664995, ...18452278
S137 Phosphorylation HPRD 19413330, 18691976, 15302935, ...18452278, 19651622, 18669648, 19415658, 20068231
S166 Phosphorylation HPRD 19651622, 18669648, 15302935, ...19664995, 20068231
S849 Phosphorylation HPRD 19413330, 18669648, 19664995, ...20068231
S851 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T59 Phosphorylation HPRD 18669648
S80 Phosphorylation HPRD 18669648
T88 Phosphorylation HPRD 17081983
T104 Phosphorylation HPRD 18669648
S126 Phosphorylation HPRD 18669648, 17081983, 19415658
S131 Phosphorylation HPRD 19413330, 18691976, 15302935, ...19664995, 18452278, 19651622, 18669648, 19415658, 20068231
Y135 Phosphorylation HPRD 19413330, 18669648, 19664995, ...18452278
Y136 Phosphorylation HPRD 19413330, 18669648, 19664995, ...18452278
S137 Phosphorylation HPRD 19413330, 18691976, 15302935, ...18452278, 19651622, 18669648, 19415658, 20068231
S166 Phosphorylation HPRD   PhosphoSitePlus 15302935
S873 Phosphorylation HPRD 19413330, 18669648, 19664995, ...20068231
S875 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O60341 (KDM1A) S131 Q8IYW5 (RNF168) unknown eFIP 25999347


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S172 L172 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
R187 Q187 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3070 / malignant glioma [ tcga ]
K271 T271 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S346 I346 Biomuta DOID:3571 / liver cancer [ icgc ]
K374 R374 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K503 N503 Biomuta DOID:3571 / liver cancer [ icgc ]
S687 I687 Biomuta DOID:3571 / liver cancer [ icgc ]
K744 E744 Biomuta DOID:1324 / lung cancer [ tcga ]
R838 C838 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]