iPTMnet Report for O60337 (MARCHF6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60337 / MARH6_HUMAN
Protein Name E3 ubiquitin-protein ligase MARCHF6
Gene Name Name: MARCHF6
Synonyms:KIAA0597,MARCH6,RNF176,TEB4;
Organism Homo sapiens (Human)

PRO ID PR:O60337
DAG View
PRO Name E3 ubiquitin-protein ligase MARCHF6 (human)
Definition An E3 ubiquitin-protein ligase MARCHF6 that is encoded in the genome of human.
Short Label hMARCHF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60337 (MARCHF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S14 Phosphorylation PhosphoSitePlus
T17 Phosphorylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
T29 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
C369 Methylation IEDB 31844290
S437 Phosphorylation PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
Y850 Phosphorylation PhosphoSitePlus
Y874 Phosphorylation PhosphoSitePlus
K878 Ubiquitination PhosphoSitePlus
K881 Ubiquitination PhosphoSitePlus
Y882 Phosphorylation PhosphoSitePlus
K897 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K20 Q20 Biomuta DOID:363 / uterine cancer [ icgc ]
T29 N29 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T29 I29 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y882 C882 Biomuta DOID:10534 / stomach cancer [ cosmic ]