iPTMnet Report for O60331 (PIP5K1C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60331 / PI51C_HUMAN
Protein Name Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Gene Name Name: PIP5K1C
Synonyms:KIAA0589;
Organism Homo sapiens (Human)

PRO ID PR:O60331
DAG View
PRO Name phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (human)
Definition A phosphatidylinositol 4-phosphate 5-kinase type-1 gamma that is encoded in the genome of human.
Short Label hPIP5K1C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60331 (PIP5K1C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K265 Acetylation UniProt 20668706
K268 Acetylation UniProt 20668706
K270 Ubiquitination PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
Y403 Phosphorylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus   RLIMS-P 30555634
S453 Phosphorylation PhosphoSitePlus
R459 Methylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
Y489 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
T543 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
T553 Phosphorylation PhosphoSitePlus
S555 Phosphorylation P31749 (AKT1) , P31751 (AKT2) PhosphoSitePlus 26149501
S556 Phosphorylation PhosphoSitePlus
K591 Sumoylation PhosphoSitePlus
Y639 Phosphorylation PhosphoSitePlus
Y649 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P   Signor   UniProt 20850356, 15738269
S650 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , P06493 (CDK1) , Q00535 (CDK5) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15738269, 30555634
S662 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S650 Phosphorylation Q00535 (CDK5) HPRD 17290217


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T47 M47 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T215 M215 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S228 L228 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K351 N351 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y403 F403 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S448 F448 Biomuta [ cosmic ]
S453 L453 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R459 C459 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S541 L541 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S544 L544 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
Y649 H649 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]