iPTMnet Report for O60315 (ZEB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60315 / ZEB2_HUMAN
Protein Name Zinc finger E-box-binding homeobox 2
Gene Name Name: ZEB2
Synonyms:KIAA0569,SIP1,ZFHX1B,ZFX1B;ORFNames:HRIHFB2411;
Organism Homo sapiens (Human)

PRO ID PR:O60315
DAG View
PRO Name zinc finger E-box-binding homeobox 2 (human)
Definition A zinc finger E-box-binding homeobox 2 that is encoded in the genome of human.
Short Label hZEB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60315 (ZEB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R11 Methylation PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
T119 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y147 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus   UniProt 23186163
T362 Phosphorylation PhosphoSitePlus
K377 Acetylation PhosphoSitePlus   UniProt 19608861
K391 Sumoylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
T470 Phosphorylation PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
S647 Phosphorylation PhosphoSitePlus   UniProt 23186163
S703 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
S726 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
S741 Phosphorylation PhosphoSitePlus
S778 Phosphorylation PhosphoSitePlus
S780 Phosphorylation PhosphoSitePlus
T782 Phosphorylation PhosphoSitePlus   UniProt 23186163
S784 Phosphorylation PhosphoSitePlus   UniProt 23186163
S796 Phosphorylation PhosphoSitePlus
T802 Phosphorylation PhosphoSitePlus
S805 Phosphorylation PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
S829 Phosphorylation PhosphoSitePlus
T837 Phosphorylation PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
S841 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S843 Phosphorylation phospho.ELM 18669648
S848 Phosphorylation phospho.ELM 18669648
S853 Phosphorylation phospho.ELM 18669648
K866 Sumoylation PhosphoSitePlus
S1050 Phosphorylation PhosphoSitePlus
S1115 Phosphorylation PhosphoSitePlus
T1117 Phosphorylation PhosphoSitePlus
S1122 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1124 Phosphorylation PhosphoSitePlus
S1129 Phosphorylation PhosphoSitePlus
S1136 Phosphorylation PhosphoSitePlus
S1167 Phosphorylation PhosphoSitePlus
T1185 Phosphorylation PhosphoSitePlus
S1189 Phosphorylation PhosphoSitePlus
S1193 Phosphorylation PhosphoSitePlus
S1194 Phosphorylation PhosphoSitePlus
S1203 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T782 Phosphorylation HPRD 19413330
S784 Phosphorylation HPRD 19413330
S1203 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T119 S119 Biomuta DOID:1324 / lung cancer [ tcga ]
T119 N119 Biomuta DOID:3571 / liver cancer [ icgc ]
Y147 * Biomuta DOID:3571 / liver cancer [ icgc ]
S162 T162 Biomuta DOID:2394 / ovarian cancer [ tcga ]
T254 N254 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T285 K285 Biomuta DOID:3571 / liver cancer [ icgc ]
S305 T305 Biomuta DOID:0070003 / blastoma [ cosmic ]
S324 F324 Biomuta DOID:1909 / melanoma [ icgc, tcga ] DOID:5041 / esophageal cancer [ tcga ]
S327 L327 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ]
S330 R330 Biomuta DOID:1324 / lung cancer [ tcga ]
T350 K350 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
T350 M350 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S352 Y352 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ]
S356 Y356 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1324 / lung cancer [ tcga ]
S359 C359 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S360 Y360 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T470 N470 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T470 I470 Biomuta DOID:184 / bone cancer [ icgc ]
S505 Y505 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ] DOID:3571 / liver cancer [ icgc ]
K632 E632 Biomuta DOID:363 / uterine cancer [ tcga ]
S647 N647 Biomuta DOID:1909 / melanoma [ cosmic ]
S705 T705 Biomuta DOID:1909 / melanoma [ cosmic ]
S731 Y731 Biomuta DOID:4362 / cervical cancer [ tcga ]
S731 P731 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S829 I829 Biomuta DOID:1324 / lung cancer [ tcga ]
S840 I840 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S853 P853 Biomuta DOID:363 / uterine cancer [ tcga ]
K866 N866 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1050 W1050 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S1129 R1129 Biomuta DOID:3571 / liver cancer [ tcga ]
T1185 P1185 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1194 L1194 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1612 / breast cancer [ tcga ]