iPTMnet Report for O60294 (LCMT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60294 / TYW4_HUMAN
Protein Name tRNA wybutosine-synthesizing protein 4
Gene Name Name: LCMT2
Synonyms:KIAA0547,TYW4;
Organism Homo sapiens (Human)

PRO ID PR:O60294
DAG View
PRO Name tRNA wybutosine-synthesizing protein 4 (human)
Definition A tRNA wybutosine-synthesizing protein 4 that is encoded in the genome of human.
Short Label hLCMT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60294 (LCMT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R9 Methylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
K453 Sumoylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
K463 Acetylation PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
T465 O-Glycosylation GlyGen 30379171
T467 Phosphorylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T316 I316 Biomuta DOID:1324 / lung cancer [ cosmic ]
K356 N356 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S426 L426 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K468 * Biomuta DOID:1324 / lung cancer [ cosmic ]