Protein Information

Cytoscape View


UniProt AC / UniProt ID O60293 / ZC3H1_HUMAN
Protein Name Zinc finger C3H1 domain-containing protein
Gene Name Name: ZFC3H1
Synonyms:CCDC131,KIAA0546,PSRC2;
Organism Homo sapiens (Human)

PRO ID PR:O60293
DAG View
PRO Name zinc finger C3H1 domain-containing protein (human)
Definition A zinc finger C3H1 domain-containing protein that is encoded in the genome of human.
Short Label hZFC3H1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60293 (ZFC3H1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 20068231
S15 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S28 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18669648, 21406692, ...20068231
S34 Phosphorylation PhosphoSitePlus   UniProt 17525332
S42 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
R55 Methylation PhosphoSitePlus
R56 Methylation PhosphoSitePlus
R62 Methylation PhosphoSitePlus
R84 Methylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
R95 Methylation PhosphoSitePlus
R99 Methylation PhosphoSitePlus
R105 Methylation PhosphoSitePlus
R118 Methylation PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S127 Phosphorylation phospho.ELM 18669648
S128 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
R143 Methylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus   UniProt 23186163
K253 Sumoylation PhosphoSitePlus
T309 Phosphorylation PhosphoSitePlus
K319 Methylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
S352 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
T353 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus   UniProt 23186163
K384 Ubiquitination PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
S655 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus   UniProt 23186163
S714 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S717 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S719 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S724 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S726 Phosphorylation PhosphoSitePlus
S729 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
T766 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K775 Acetylation PhosphoSitePlus
K782 Ubiquitination PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
K800 Ubiquitination PhosphoSitePlus
T801 Phosphorylation phospho.ELM 18669648
S802 Phosphorylation PhosphoSitePlus
S803 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S804 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S805 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S809 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
K832 Ubiquitination PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
K880 Ubiquitination PhosphoSitePlus
K921 Acetylation PhosphoSitePlus
K926 Acetylation PhosphoSitePlus
K932 Acetylation PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus   UniProt 23186163
S949 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...16565220
S952 Phosphorylation PhosphoSitePlus
S953 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16565220
K966 Ubiquitination PhosphoSitePlus
S998 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16565220
S1046 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1050 Phosphorylation PhosphoSitePlus
T1076 Phosphorylation PhosphoSitePlus
S1096 Phosphorylation PhosphoSitePlus
S1100 Phosphorylation PhosphoSitePlus
K1102 Ubiquitination PhosphoSitePlus
S1148 Phosphorylation PhosphoSitePlus
Y1161 Phosphorylation PhosphoSitePlus
Y1162 Phosphorylation PhosphoSitePlus
Y1244 Phosphorylation PhosphoSitePlus
K1247 Ubiquitination PhosphoSitePlus
T1276 Phosphorylation PhosphoSitePlus
K1287 Methylation PhosphoSitePlus
K1295 Ubiquitination PhosphoSitePlus
S1298 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1301 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1303 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S1304 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S1849 Phosphorylation PhosphoSitePlus
K1955 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD 19691289, 20068231
S28 Phosphorylation HPRD 19651622, 17525332, 18669648, ...20068231, 18452278
S34 Phosphorylation HPRD 17525332
S40 Phosphorylation HPRD 20068231
S41 Phosphorylation HPRD 20068231
S42 Phosphorylation HPRD 20068231
S43 Phosphorylation HPRD 20068231
S44 Phosphorylation HPRD 20068231
S127 Phosphorylation HPRD 18669648
S128 Phosphorylation HPRD 18669648
S352 Phosphorylation HPRD 19651622, 18767875, 18669648, ...19691289, 20068231
S714 Phosphorylation HPRD 19651622, 18669648
S717 Phosphorylation HPRD 19651622, 18669648
S719 Phosphorylation HPRD 19651622, 18669648, 19691289
S724 Phosphorylation HPRD 18669648
T766 Phosphorylation HPRD 18669648, 20068231
T801 Phosphorylation HPRD 18669648
S803 Phosphorylation HPRD 18669648
S804 Phosphorylation HPRD 19413330, 18669648
S805 Phosphorylation HPRD 19413330, 18767875, 18452278, ...19651622, 18669648, 20068231
S809 Phosphorylation HPRD 19413330, 19691289, 19651622, ...18669648, 19415658, 20068231
S948 Phosphorylation HPRD 20068231
S949 Phosphorylation HPRD 19413330, 19664994, 19007248, ...16565220, 19651622, 18669648, 20068231, 19691289
S952 Phosphorylation HPRD 20068231
S953 Phosphorylation HPRD 19413330, 19691289, 16565220, ...18669648, 19007248, 20068231
S998 Phosphorylation HPRD 18669648, 16565220
S1046 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S1298 Phosphorylation HPRD 18669648, 19691289, 20068231
S1301 Phosphorylation HPRD 19651622, 18669648, 20068231
S1303 Phosphorylation HPRD 19651622, 18669648, 19691289, ...20068231, 18452278
S1304 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S28 R28 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S34 R34 Biomuta DOID:3571 / liver cancer [ icgc ]
S40 I40 Biomuta DOID:1909 / melanoma [ cosmic ]
S43 I43 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S44 G44 Biomuta DOID:363 / uterine cancer [ tcga ]
S44 R44 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S45 R45 Biomuta DOID:3571 / liver cancer [ icgc ]
S45 G45 Biomuta DOID:169 / neuroendocrine tumor [ tcga ] DOID:3070 / malignant glioma [ tcga ] DOID:363 / uterine cancer [ tcga ] DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ tcga ] DOID:10534 / stomach cancer [ tcga ] DOID:1115 / sarcoma [ tcga ] DOID:11934 / head and neck cancer [ tcga ]
S87 * Biomuta DOID:1909 / melanoma [ tcga ]
S121 W121 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S121 L121 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ tcga ]
S122 R122 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S128 R128 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S128 I128 Biomuta DOID:1324 / lung cancer [ cosmic ]
S199 N199 Biomuta DOID:3070 / malignant glioma [ tcga ]
S206 Y206 Biomuta DOID:363 / uterine cancer [ tcga ]
K253 N253 Biomuta DOID:363 / uterine cancer [ tcga ]
S328 F328 Biomuta DOID:363 / uterine cancer [ tcga ]
S352 N352 Biomuta DOID:3070 / malignant glioma [ cosmic ]
S352 I352 Biomuta DOID:1612 / breast cancer [ icgc ]
S381 T381 Biomuta DOID:1324 / lung cancer [ cosmic ]
S500 R500 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S662 * Biomuta DOID:3571 / liver cancer [ icgc ]
S717 G717 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K782 N782 Biomuta DOID:363 / uterine cancer [ tcga ]
K848 N848 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
T1276 N1276 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1303 N1303 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]