iPTMnet Report for O60291 (MGRN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60291 / MGRN1_HUMAN
Protein Name E3 ubiquitin-protein ligase MGRN1
Gene Name Name: MGRN1
Synonyms:KIAA0544,RNF156;
Organism Homo sapiens (Human)

PRO ID PR:O60291
DAG View
PRO Name E3 ubiquitin-protein ligase MGRN1 (human)
Definition An E3 ubiquitin-protein ligase MGRN1 that is encoded in the genome of human.
Short Label hMGRN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60291 (MGRN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 20213681
K82 Ubiquitination PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
K101 Acetylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
L156 Methylation IEDB 32357974
K164 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
Y254 Phosphorylation PhosphoSitePlus
K259 Acetylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
C293 Methylation IEDB 31844290
C302 Methylation IEDB 33981976, 31844290
K332 Ubiquitination PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
Y411 Phosphorylation PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
Y416 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
T454 Phosphorylation phospho.ELM 18669648
S457 Phosphorylation PhosphoSitePlus
S459 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S460 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S524 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Site PTM Type PTM Enzyme Score Source PMID
T454 Phosphorylation HPRD 18669648
S459 Phosphorylation HPRD 18669648
S524 Phosphorylation HPRD 18669648, 20068231
Y537 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S342 Phosphorylation PhosphoSitePlus
Y515 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S155 L155 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S361 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S402 F402 Biomuta DOID:4159 / skin cancer [ cosmic ]
S402 C402 Biomuta DOID:1324 / lung cancer [ cosmic ]
S407 L407 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ] DOID:11934 / head and neck cancer [ icgc ]
S407 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S417 P417 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K449 N449 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S459 Y459 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S460 F460 Biomuta DOID:4159 / skin cancer [ cosmic ]
S492 F492 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S523 N523 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]