iPTMnet Report for O60271 (SPAG9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60271 / JIP4_HUMAN
Protein Name C-Jun-amino-terminal kinase-interacting protein 4
Gene Name Name: SPAG9
Synonyms:HSS,KIAA0516,MAPK8IP4,SYD1;ORFNames:HLC6;
Organism Homo sapiens (Human)

PRO ID PR:O60271
DAG View
PRO Name C-Jun-amino-terminal kinase-interacting protein 4 (human)
Definition A C-Jun-amino-terminal kinase-interacting protein 4 that is encoded in the genome of human.
Short Label hSPAG9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60271 (SPAG9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
Y9 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S109 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
S123 Phosphorylation PhosphoSitePlus
K134 Sumoylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S183 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18669648, 20068231
S185 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18669648, 24275569
S190 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus   UniProt 20068231
S203 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 19690332, 20068231
T217 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 19690332, 20068231
T226 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S229 Phosphorylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S238 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S242 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T244 Phosphorylation phospho.ELM 18669648
S245 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S249 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus   UniProt 20068231, 24275569
S265 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18669648, ...20068231
S268 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18669648, 20068231
S272 Phosphorylation PhosphoSitePlus   UniProt 17525332, 20068231
T275 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T276 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S279 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
T290 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T292 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S311 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S314 Phosphorylation PhosphoSitePlus
S329 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
T330 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
S339 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S347 Phosphorylation PhosphoSitePlus   UniProt 20068231
T348 Phosphorylation PhosphoSitePlus   UniProt 20068231
S358 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S364 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T365 Phosphorylation PhosphoSitePlus
T367 Phosphorylation PhosphoSitePlus
S387 Phosphorylation phospho.ELM 17081983
S388 Phosphorylation phospho.ELM 17081983
S391 Phosphorylation phospho.ELM 17081983
T418 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18669648, 20068231
K445 Ubiquitination PhosphoSitePlus
R474 Methylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
K577 Methylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
Y578 Phosphorylation PhosphoSitePlus
T582 Phosphorylation PhosphoSitePlus
T586 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18847512
S588 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S593 Phosphorylation PhosphoSitePlus
S594 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T595 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163
S597 Phosphorylation PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
K653 Ubiquitination PhosphoSitePlus
Y654 Phosphorylation PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus   UniProt 23186163
S710 Phosphorylation PhosphoSitePlus
Y713 Phosphorylation PhosphoSitePlus
S728 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18669648, 23186163
S730 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 15302935, ...18669648, 20068231
S732 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 15302935, 15144186, ...18669648, 24275569
S733 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15302935, ...15144186, 18669648, 24275569, 19690332, 20068231
K742 Acetylation PhosphoSitePlus
K746 Acetylation PhosphoSitePlus
K749 Acetylation PhosphoSitePlus
S813 Phosphorylation PhosphoSitePlus
S815 Phosphorylation PhosphoSitePlus
Y914 Phosphorylation PhosphoSitePlus
S949 Phosphorylation PhosphoSitePlus
K998 Ubiquitination PhosphoSitePlus
Y1115 Phosphorylation IEDB 35494241
S1144 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1188 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1227 Ubiquitination PhosphoSitePlus
S1238 Phosphorylation PhosphoSitePlus
T1264 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163
S1290 Phosphorylation PhosphoSitePlus
S1302 Phosphorylation PhosphoSitePlus
K1305 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S183 Phosphorylation phospho.ELM 18669648, 18220336
S185 Phosphorylation phospho.ELM 18669648, 18220336
S203 Phosphorylation phospho.ELM 18669648
T217 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T226 Phosphorylation phospho.ELM 18669648
S238 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
T244 Phosphorylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
T262 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S265 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S109 Phosphorylation HPRD 17525332, 20068231
S183 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S185 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S190 Phosphorylation HPRD 20068231
S194 Phosphorylation HPRD 20068231
S203 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231
T217 Phosphorylation HPRD 17081983, 20058876, 19651622, ...18669648, 18707149, 20068231
T226 Phosphorylation HPRD 19413330, 18669648, 19664994, ...20068231, 18707149
S229 Phosphorylation HPRD 20068231
S238 Phosphorylation HPRD 18077418, 18669648, 20068231
S242 Phosphorylation HPRD 19651622, 17287340
T244 Phosphorylation HPRD 19651622
S245 Phosphorylation HPRD 17525332, 17287340, 18077418
S251 Phosphorylation HPRD 19651622, 17525332, 18077418
S254 Phosphorylation HPRD 19651622, 17525332, 18077418
S258 Phosphorylation HPRD 19651622
T261 Phosphorylation HPRD 18669648, 20068231
T262 Phosphorylation HPRD 19413330, 18669648
T276 Phosphorylation HPRD 18669648
T278 Phosphorylation HPRD 18669648
S297 Phosphorylation HPRD 18669648
S315 Phosphorylation HPRD 19651622, 18669648, 20068231
T316 Phosphorylation HPRD 18669648
S318 Phosphorylation HPRD 19651622, 18669648, 20068231
S325 Phosphorylation HPRD 18669648
S333 Phosphorylation HPRD 20068231
T334 Phosphorylation HPRD 17322306, 20068231
S349 Phosphorylation HPRD 20068231
S350 Phosphorylation HPRD 18669648
T351 Phosphorylation HPRD 20068231
S367 Phosphorylation HPRD 20068231
S373 Phosphorylation HPRD 19651622, 17081983, 20068231
S374 Phosphorylation HPRD 19651622, 17081983, 20068231
S377 Phosphorylation HPRD 19651622, 17081983, 20068231
T404 Phosphorylation HPRD 17525332, 18669648, 20068231
T572 Phosphorylation HPRD 18669648
S580 Phosphorylation HPRD 17287340
T581 Phosphorylation HPRD 17287340, 19664994
S691 Phosphorylation HPRD 20068231
Y699 Phosphorylation HPRD 20068231
S714 Phosphorylation HPRD 19413330, 20166139, 18669648, ...20068231
S716 Phosphorylation HPRD 17525332, 19651622, 18669648, ...18707149, 20166139, 19415658, 20068231
S718 Phosphorylation HPRD 20166139, 18669648, 15144186, ...20068231
S719 Phosphorylation HPRD 19413330, 15144186, 19651622, ...18669648, 18707149, 20166139, 19415658, 20068231
S1130 Phosphorylation HPRD 18669648
T1250 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S109 C109 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K134 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S190 F190 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S203 L203 Biomuta [ cosmic ]
T226 I226 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S238 C238 Biomuta DOID:1324 / lung cancer [ cosmic ]
S242 Y242 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S254 I254 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S265 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S268 I268 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S279 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S297 L297 Biomuta DOID:4159 / skin cancer [ cosmic ]
S311 L311 Biomuta DOID:4159 / skin cancer [ cosmic ]
S325 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S339 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S350 I350 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S358 N358 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S364 I364 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S561 G561 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K577 M577 Biomuta [ cosmic ]
T582 M582 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K749 E749 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S949 * Biomuta DOID:363 / uterine cancer [ cosmic ] [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S1130 C1130 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1130 F1130 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1144 C1144 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1144 F1144 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1250 M1250 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T1264 M1264 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1290 T1290 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1290 L1290 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1305 N1305 Biomuta DOID:3571 / liver cancer [ cosmic ]