iPTMnet Report for O60260 (PRKN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60260 / PRKN_HUMAN
Protein Name E3 ubiquitin-protein ligase parkin
Gene Name Name: PRKN
Synonyms:PARK2;
Organism Homo sapiens (Human)

PRO ID PR:O60260
DAG View
PRO Name E3 ubiquitin-protein ligase parkin (human)
Definition An E3 ubiquitin-protein ligase parkin that is encoded in the genome of human.
Short Label hPRKN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60260 (PRKN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S9 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
S65 Phosphorylation Q9BXM7 (PINK1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 24660806, 23754282, 25474007, ...24784582, 26161729, 33112198, 18957282, 36217155, 22724072
K76 Acetylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
S101 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus 15557340
S108 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus   RLIMS-P 35191952, 35105670
K129 Acetylation PhosphoSitePlus
S131 Phosphorylation Q00535 (CDK5) phospho.ELM   PhosphoSitePlus   Signor 15557340, 17327227
S136 Phosphorylation phospho.ELM   PhosphoSitePlus 15557340
Y143 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor 21209200, 20823226
T175 Phosphorylation UniProt 18957282
S193 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
T204 Phosphorylation PhosphoSitePlus
T217 Phosphorylation UniProt 18957282
K220 Acetylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
S296 Phosphorylation phospho.ELM   PhosphoSitePlus 15557340
K349 Acetylation PhosphoSitePlus
Y372 Phosphorylation PhosphoSitePlus
S378 Phosphorylation P48729 (CSNK1A1) , P53350 (PLK1) phospho.ELM   PhosphoSitePlus 26387737, 15557340
T388 Phosphorylation PhosphoSitePlus
Y391 Phosphorylation PhosphoSitePlus
K408 Acetylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048694 (hPRKN/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 A9 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S10 I10 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K48 N48 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K76 E76 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S108 N108 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S110 T110 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S127 N127 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K129 N129 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K129 M129 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T204 S204 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K220 N220 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S296 F296 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y372 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S378 G378 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K408 N408 Biomuta DOID:10534 / stomach cancer [ cosmic ]