Protein Information

Cytoscape View


UniProt AC / UniProt ID O60244 / MED14_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 14
Gene Name Name: MED14
Synonyms:ARC150,CRSP2,CXorf4,DRIP150,EXLM1,RGR1,TRAP170;
Organism Homo sapiens (Human)

PRO ID PR:O60244
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 14 (human)
Definition A mediator of RNA polymerase II transcription subunit 14 that is encoded in the genome of human.
Short Label hMED14
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60244 (MED14) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K111 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
T184 Phosphorylation HPRD   PhosphoSitePlus 20068231
K185 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K399 Methylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
S617 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
K691 Ubiquitination PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
Y901 Phosphorylation PhosphoSitePlus
Y927 Phosphorylation PhosphoSitePlus
Y941 Phosphorylation PhosphoSitePlus
K948 Ubiquitination PhosphoSitePlus
S977 Phosphorylation HPRD   PhosphoSitePlus 18452278
S986 Phosphorylation P27361 (MAPK3) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 24049075, 19369195, 15302935, ...18452278
S1061 Phosphorylation PhosphoSitePlus
S1112 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19690332, 20068231
S1116 Phosphorylation PhosphoSitePlus
S1119 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 20068231
R1123 Methylation PhosphoSitePlus
S1128 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
S1133 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S1136 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S1142 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1144 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
R1146 Methylation PhosphoSitePlus
S1151 Phosphorylation PhosphoSitePlus
K1256 Ubiquitination PhosphoSitePlus
K1264 Ubiquitination PhosphoSitePlus
K1274 Ubiquitination PhosphoSitePlus
K1283 Ubiquitination PhosphoSitePlus
K1295 Ubiquitination PhosphoSitePlus
K1304 Ubiquitination PhosphoSitePlus
T1354 Phosphorylation PhosphoSitePlus
K1360 Ubiquitination PhosphoSitePlus
S1361 Phosphorylation PhosphoSitePlus
K1420 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04150 (NR3C1) S211 O60244 (MED14) increased_association eFIP 18483179


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K176 R176 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K176 T176 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K185 R185 Biomuta DOID:363 / uterine cancer [ tcga ]
K384 I384 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K384 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K535 E535 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S986 T986 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R1123 H1123 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic ]
S1128 T1128 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R1146 Q1146 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
K1283 R1283 Biomuta DOID:363 / uterine cancer [ tcga ]
T1354 M1354 Biomuta DOID:363 / uterine cancer [ tcga ]