iPTMnet Report for O60244 (MED14)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60244 / MED14_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 14
Gene Name Name: MED14
Synonyms:ARC150,CRSP2,CXorf4,DRIP150,EXLM1,RGR1,TRAP170;
Organism Homo sapiens (Human)

PRO ID PR:O60244
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 14 (human)
Definition A mediator of RNA polymerase II transcription subunit 14 that is encoded in the genome of human.
Short Label hMED14
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60244 (MED14) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K111 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
T184 Phosphorylation HPRD   PhosphoSitePlus 20068231
K185 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
T191 O-Glycosylation GlyGen 30379171, 33214551, 34019948
C334 Methylation IEDB 31844290
K356 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K399 Methylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
S481 Phosphorylation IEDB 35494241
K510 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
T604 O-Glycosylation GlyGen 30379171, 33214551, 34019948
S617 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
C635 Methylation IEDB 31844290
K691 Ubiquitination PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
C708 Methylation IEDB 31844290
C779 Methylation IEDB 31844290
Y901 Phosphorylation PhosphoSitePlus
C903 Methylation IEDB 31844290
Y927 Phosphorylation PhosphoSitePlus
Y941 Phosphorylation PhosphoSitePlus
K948 Ubiquitination PhosphoSitePlus
S977 Phosphorylation HPRD   PhosphoSitePlus 18452278
S986 Phosphorylation P27361 (MAPK3) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 24049075, 19369195, 15302935, ...18452278
S1061 Phosphorylation PhosphoSitePlus
S1112 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19690332, 20068231
S1116 Phosphorylation PhosphoSitePlus
S1119 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 20068231
R1123 Methylation PhosphoSitePlus
S1128 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
S1133 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S1136 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S1142 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1144 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
R1146 Methylation PhosphoSitePlus
S1151 Phosphorylation PhosphoSitePlus
K1256 Ubiquitination PhosphoSitePlus
K1264 Ubiquitination PhosphoSitePlus
K1274 Ubiquitination PhosphoSitePlus
K1283 Ubiquitination PhosphoSitePlus
K1295 Ubiquitination PhosphoSitePlus
K1304 Ubiquitination PhosphoSitePlus
C1316 Methylation IEDB 31844290
T1354 Phosphorylation PhosphoSitePlus
K1360 Ubiquitination PhosphoSitePlus
S1361 Phosphorylation PhosphoSitePlus
K1420 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04150 (NR3C1) S211 O60244 (MED14) increased_association eFIP 18483179


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K176 R176 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K176 T176 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K384 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K384 I384 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K412 N412 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K535 E535 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S986 T986 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1116 F1116 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R1123 H1123 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R1123 C1123 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1128 T1128 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R1146 Q1146 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K1283 R1283 Biomuta DOID:363 / uterine cancer [ icgc ]
T1354 M1354 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]