iPTMnet Report for O60237 (PPP1R12B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60237 / MYPT2_HUMAN
Protein Name Protein phosphatase 1 regulatory subunit 12B
Gene Name Name: PPP1R12B
Synonyms:MYPT2;
Organism Homo sapiens (Human)

PRO ID PR:O60237
DAG View
PRO Name protein phosphatase 1 regulatory subunit 12B (human)
Definition A protein phosphatase 1 regulatory subunit 12B that is encoded in the genome of human.
Short Label hPPP1R12B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60237 (PPP1R12B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus   RLIMS-P 22937917
T31 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
Y340 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
T445 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
Y493 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus   RLIMS-P 22937917
S506 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
T527 Phosphorylation PhosphoSitePlus
T543 O-Glycosylation GlyGen 30379171, 32938750, 30059200, ...30620550, 35132862, 31492838, 35254053, 28657654
Y549 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
T565 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
Y619 Phosphorylation PhosphoSitePlus
T621 Phosphorylation PhosphoSitePlus
T642 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus   RLIMS-P 22937917
T646 Phosphorylation Q13464 (ROCK1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 22937917, 16431080
T650 Phosphorylation PhosphoSitePlus
T652 Phosphorylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus   RLIMS-P 22937917
S735 Phosphorylation PhosphoSitePlus
Y744 Phosphorylation PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus   RLIMS-P 22937917
S762 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus
T808 Phosphorylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
S839 Phosphorylation PhosphoSitePlus   RLIMS-P 22937917
S842 Phosphorylation PhosphoSitePlus
T845 Phosphorylation PhosphoSitePlus
T846 Phosphorylation PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
S849 Phosphorylation PhosphoSitePlus
R853 Methylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
T869 Phosphorylation PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
S947 Phosphorylation PhosphoSitePlus
S981 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation HPRD 18212344
S447 Phosphorylation HPRD 18691976
T681 Phosphorylation HPRD 20068231
S687 Phosphorylation HPRD 20068231
S878 Phosphorylation HPRD 19664995
S947 Phosphorylation HPRD 17322306
Site PTM Type PTM Enzyme Score Source PMID
S104 Phosphorylation HPRD 19664995
Site PTM Type PTM Enzyme Score Source PMID
S104 Phosphorylation HPRD 19664995
S173 Phosphorylation HPRD 17322306


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S104 N104 Biomuta [ cosmic, cosmic ] DOID:2531 / hematologic cancer [ cosmic, cosmic ]
K303 R303 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S374 P374 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S434 C434 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S471 F471 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S472 F472 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S474 I474 Biomuta DOID:1612 / breast cancer [ cosmic ]
S506 T506 Biomuta DOID:263 / kidney cancer [ cosmic ]
S561 F561 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T565 K565 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S618 F618 Biomuta DOID:4159 / skin cancer [ cosmic ]
S760 Y760 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S835 Y835 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R853 W853 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S855 A855 Biomuta DOID:4159 / skin cancer [ cosmic ]
S855 L855 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T869 I869 Biomuta DOID:4159 / skin cancer [ cosmic ]
T869 A869 Biomuta DOID:1324 / lung cancer [ cosmic ]
S878 N878 Biomuta [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]