iPTMnet Report for O60218 (AKR1B10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60218 / AK1BA_HUMAN
Protein Name Aldo-keto reductase family 1 member B10
Gene Name Name: AKR1B10
Synonyms:AKR1B11;
Organism Homo sapiens (Human)

PRO ID PR:O60218
DAG View
PRO Name aldo-keto reductase family 1 member B10 (human)
Definition An aldo-keto reductase family 1 member B10 that is encoded in the genome of human.
Short Label hAKR1B10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60218 (AKR1B10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation HPRD   PhosphoSitePlus 19415658
K27 Acetylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
R70 Methylation PhosphoSitePlus
K95 Acetylation PhosphoSitePlus
K125 Acetylation PhosphoSitePlus   UniProt 19608861
K128 Methylation PhosphoSitePlus
T137 Phosphorylation IEDB   PhosphoSitePlus 27869121
K169 Acetylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
K263 Acetylation PhosphoSitePlus   UniProt 19608861
S282 Phosphorylation PhosphoSitePlus
T288 Phosphorylation HPRD   PhosphoSitePlus 20068231
S291 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y310 Phosphorylation PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 P23 Biomuta DOID:3571 / liver cancer [ cosmic ]
K27 T27 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y47 C47 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R70 Q70 Biomuta [ cosmic ]
K95 E95 Biomuta DOID:1319 / brain cancer [ cosmic ]
T137 M137 Biomuta DOID:1319 / brain cancer [ icgc ]
K263 T263 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K263 N263 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y316 F316 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]