iPTMnet Report for O60216 (RAD21)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60216 / RAD21_HUMAN
Protein Name Double-strand-break repair protein rad21 homolog
Gene Name Name: RAD21
Synonyms:HR21;
Organism Homo sapiens (Human)

PRO ID PR:O60216
DAG View
PRO Name double-strand-break repair protein rad21 homolog (human)
Definition A double-strand-break repair protein rad21 homolog that is encoded in the genome of human.
Short Label hRAD21
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60216 (RAD21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Sumoylation PRO
S9 Phosphorylation HPRD   PhosphoSitePlus 19413330
K29 Ubiquitination PhosphoSitePlus
C35 Methylation IEDB 31844290
S40 Phosphorylation PhosphoSitePlus
S46 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 20068231
K48 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
Y67 Phosphorylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
C78 Methylation IEDB 31844290
K84 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
S134 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S138 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T144 Phosphorylation PhosphoSitePlus   RLIMS-P 15737063
S153 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18452278, 22067460, 18669648, ...24275569, 19690332, 20068231
S175 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 19690332, ...18452278
S185 Phosphorylation PhosphoSitePlus
T186 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 15737063
T187 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
Y211 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
K216 Sumoylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus   UniProt 24275569
S277 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S280 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T289 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T312 Phosphorylation PhosphoSitePlus   RLIMS-P 15737063
K323 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S342 Phosphorylation HPRD 20068231
Y344 Phosphorylation PhosphoSitePlus
S345 Phosphorylation HPRD 20068231
T350 Phosphorylation HPRD 20068231
K358 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
T366 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K371 Ubiquitination PhosphoSitePlus
S374 Phosphorylation HPRD   PhosphoSitePlus 20068231
K387 Ubiquitination PhosphoSitePlus
T394 Phosphorylation PhosphoSitePlus   UniProt 23186163
K406 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P   UniProt 15737063, 23186163
S459 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
S545 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163
K573 Ubiquitination PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
Y598 Phosphorylation PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
T623 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048992 (hRAD21/Phos:1) pS454 PRO
PR:000048993 (hRAD21/SumoLys+) su PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 G9 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K29 E29 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K29 T29 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S56 P56 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y67 C67 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y67 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T144 A144 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T144 P144 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S175 G175 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T187 I187 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T187 P187 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S200 C200 Biomuta DOID:263 / kidney cancer [ cosmic ]
S200 G200 Biomuta DOID:363 / uterine cancer [ icgc ]
Y215 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S249 F249 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S280 L280 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K335 M335 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K335 N335 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K358 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K364 N364 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K371 T371 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S374 F374 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
K387 Q387 Biomuta DOID:3571 / liver cancer [ cosmic ]
T394 A394 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S454 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S459 N459 Biomuta DOID:1319 / brain cancer [ cosmic ]
S466 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K596 E596 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]