Protein Information

Cytoscape View


UniProt AC / UniProt ID O43929 / ORC4_HUMAN
Protein Name Origin recognition complex subunit 4
Gene Name Name: ORC4
Synonyms:ORC4L;
Organism Homo sapiens (Human)

PRO ID PR:O43929
DAG View
PRO Name origin recognition complex subunit 4 (human)
Definition An origin recognition complex subunit 4 that is encoded in the genome of human.
Short Label hORC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43929 (ORC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
K7 Methylation PhosphoSitePlus   UniProt 24129315
S10 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
R260 Methylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 20068231
S35 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K7 M7 Biomuta DOID:1324 / lung cancer [ cosmic ]
K7 N7 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S10 N10 Biomuta DOID:363 / uterine cancer [ tcga ]
S35 R35 Biomuta DOID:363 / uterine cancer [ tcga ]
R260 I260 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K360 I360 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K386 R386 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]