iPTMnet Report for O43929 (ORC4)
Protein Information
| UniProt AC / UniProt ID | O43929 / ORC4_HUMAN |
| Protein Name | Origin recognition complex subunit 4 |
| Gene Name | Name: ORC4 Synonyms:ORC4L; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O43929 |
| PRO Name | origin recognition complex subunit 4 (human) |
| Definition | An origin recognition complex subunit 4 that is encoded in the genome of human. |
| Short Label | hORC4 |
| Category | organism-gene |
O43929 (ORC4) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S6 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K7 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
| S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S48 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K52 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T54 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K112 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K204 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K231 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S235 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K243 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K248 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R260 | Methylation | score1 | PhosphoSitePlus | |||
| K268 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K360 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K369 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K386 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K7 | M7 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K7 | N7 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S10 | N10 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S35 | R35 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K52 | R52 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T54 | A54 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| R260 | I260 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| K360 | I360 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| K386 | R386 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] |
DAG View