Protein Information

Cytoscape View


UniProt AC / UniProt ID O43914 / TYOBP_HUMAN
Protein Name TYRO protein tyrosine kinase-binding protein precursor
Gene Name Name: TYROBP
Synonyms:DAP12;
Organism Homo sapiens (Human)

PRO ID PR:O43914
DAG View
PRO Name TYRO protein tyrosine kinase-binding protein (human)
Definition A TYRO protein tyrosine kinase-binding protein that is encoded in the genome of human.
Short Label hTYROBP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43914 (TYROBP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S89 Phosphorylation PhosphoSitePlus
Y91 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 18083107, 9490415
Y91 Phosphorylation P43405 (SYK) phospho.ELM 9490415
Y102 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 9490415
Y102 Phosphorylation P43405 (SYK) phospho.ELM 9490415
Y111 Phosphorylation PhosphoSitePlus
Y112 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y91 Phosphorylation HPRD 9490415
Y91 Phosphorylation P43405 (SYK) HPRD 9490415
Y102 Phosphorylation HPRD 9490415
Y102 Phosphorylation P43405 (SYK) HPRD 9490415
Site PTM Type PTM Enzyme Score Source PMID
Y90 Phosphorylation HPRD   PhosphoSitePlus 9490415
Y90 Phosphorylation P43405 (SYK) HPRD 9490415
Y101 Phosphorylation HPRD   PhosphoSitePlus 9490415
Y101 Phosphorylation P43405 (SYK) HPRD 9490415
Y110 Phosphorylation PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049575 (hTYROBP/SigPep-/Phos:1) pY91,pY102 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S89 * Biomuta DOID:3571 / liver cancer [ icgc ]
S89 L89 Biomuta DOID:1909 / melanoma [ cosmic ]
Y102 N102 Biomuta DOID:1324 / lung cancer [ cosmic ]