iPTMnet Report O43914 TYROBP

Protein Information

Cytoscape View

UniProt AC / UniProt ID	O43914 / TYOBP_HUMAN
Protein Name	TYRO protein tyrosine kinase-binding protein precursor
Gene Name	Name: TYROBP Synonyms:DAP12;
Organism	Homo sapiens (Human)

PRO ID	PR:O43914 DAG View
PRO Name	TYRO protein tyrosine kinase-binding protein (human)
Definition	A TYRO protein tyrosine kinase-binding protein that is encoded in the genome of human.
Short Label	hTYROBP
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O43914 (TYROBP) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S89	Phosphorylation		score1	PhosphoSitePlus
	Y91	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus	18083107, 9490415
	Y91	Phosphorylation	P43405 (SYK)	score2	phospho.ELM	9490415
	Y102	Phosphorylation		score3	phospho.ELM PRO PhosphoSitePlus	9490415
	Y102	Phosphorylation	P43405 (SYK)	score2	phospho.ELM	9490415
	Y111	Phosphorylation		score1	PhosphoSitePlus
	Y112	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y91	Phosphorylation		score1	HPRD	9490415
	Y91	Phosphorylation	P43405 (SYK)	score1	HPRD	9490415
	Y102	Phosphorylation		score1	HPRD	9490415
	Y102	Phosphorylation	P43405 (SYK)	score1	HPRD	9490415

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y90	Phosphorylation		score3	HPRD PhosphoSitePlus	9490415
	Y90	Phosphorylation	P43405 (SYK)	score1	HPRD	9490415
	Y101	Phosphorylation		score3	HPRD PhosphoSitePlus	9490415
	Y101	Phosphorylation	P43405 (SYK)	score1	HPRD	9490415
	Y110	Phosphorylation		score1	PhosphoSitePlus
	Y111	Phosphorylation		score1	PhosphoSitePlus

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000049575 (hTYROBP/SigPep-/Phos:1)	pY91,pY102		PRO

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S89	L89	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
Y101	N101	Biomuta		DOID:1324 / lung cancer [ cosmic ]
Y102	N102	Biomuta		DOID:1324 / lung cancer [ cosmic ]