iPTMnet Report for O43913 (ORC5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43913 / ORC5_HUMAN
Protein Name Origin recognition complex subunit 5
Gene Name Name: ORC5
Synonyms:ORC5L;
Organism Homo sapiens (Human)

PRO ID PR:O43913
DAG View
PRO Name origin recognition complex subunit 5 (human)
Definition An origin recognition complex subunit 5 that is encoded in the genome of human.
Short Label hORC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43913 (ORC5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C63 Methylation IEDB 31844290
S86 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
Y236 Phosphorylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
T286 O-Glycosylation GlyGen 28510447, 35254053
K292 Ubiquitination PhosphoSitePlus
K330 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K263 E263 Biomuta DOID:1319 / brain cancer [ cosmic ]
S274 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K283 E283 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]