iPTMnet Report for O43889 (CREB3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43889 / CREB3_HUMAN
Protein Name Cyclic AMP-responsive element-binding protein 3
Gene Name Name: CREB3
Synonyms:LZIP;
Organism Homo sapiens (Human)

PRO ID PR:O43889
DAG View
PRO Name cyclic AMP-responsive element-binding protein 3 (human)
Definition A cyclic AMP-responsive element-binding protein 3 that is encoded in the genome of human.
Short Label hCREB3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43889 (CREB3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
N348 N-Glycosylation GlyGen 24190977
K352 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S89 F89 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K132 N132 Biomuta DOID:3571 / liver cancer [ cosmic ]
K172 E172 Biomuta DOID:1324 / lung cancer [ cosmic ]
N348 S348 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N348 D348 Biomuta DOID:9256 / colorectal cancer [ cosmic ]